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  Significant improvement in neuropsychological functions after awake craniotomy in a patient with oligodendroglioma: A case report

Thomas, M., Scheer, M., Spindler, K., Nieberlein, L., Hartwigsen, G., Gussew, A., et al. (2023). Significant improvement in neuropsychological functions after awake craniotomy in a patient with oligodendroglioma: A case report. Interdisciplinary Neurosurgery, 33: 101796. doi:10.1016/j.inat.2023.101796.

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 Creators:
Thomas, Mareike1, Author
Scheer, Maximilian2, Author
Spindler, Kai2, Author
Nieberlein, Laura3, Author           
Hartwigsen, Gesa3, Author                 
Gussew, Alexander4, Author
Schob, Stefan4, Author
Prell, Julian2, Author
Strauss, Christian2, Author
Rampp, Stefan2, 5, Author
Affiliations:
1Department of Psychology, Martin Luther University Halle-Wittenberg, Germany, ou_persistent22              
2Department of Neurosurgery, Martin Luther University Halle-Wittenberg, Germany, ou_persistent22              
3Lise Meitner Research Group Cognition and Plasticity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3025665              
4Department of Radiology, Martin Luther University Halle-Wittenberg, Germany, ou_persistent22              
5Department of Neurosurgery, University Clinic Erlangen, Germany, ou_persistent22              

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Free keywords: Neuropsychological assessment; Glioma; Awake craniotomy; Improvement of cognitive functions
 Abstract: Objective
The goal of awake craniotomy in glioma patients is sparing of cognitive function. Previous investigations suggest that patients in the postoperative state may reach their preoperative level regarding domain-based criteria. Data on significant postoperative improvement beyond the preoperative level is sparse. This article examines the prospective neuropsychological assessment of a glioma patient who underwent awake craniotomy and has shown functional improvement exceeding preoperative levels.

Methods
A 34-year-old patient with high premorbid cognitive function level who underwent awake craniotomy for left frontal oligodendroglioma was neuropsychologically assessed and took part in a fMRI-examination at 3 different time points.

Results
Preoperative examination revealed severe isolated impairment of working memory, long-term narrative memory in free recall and recognition, and alertness with intact language production and comprehension. After transient global aphasia in the postoperative state, the follow-up examination showed significant improvement in memory and attention exceeding the preoperative level.

Conclusions
Tumor location is an important factor in terms of surgical procedures. Cognitive impairment is, however, not always associated with a specific location. Mechanical pressure of the tumor might have led to the isolated consolidation deficit which fully recovered after tumor removal. Psychological disorders should be taken into account regarding prodromal symptoms of neurooncological diseases.

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Language(s): eng - English
 Dates: 2023-05-032023-01-162023-06-032023-06-052023-09
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.inat.2023.101796
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Title: Interdisciplinary Neurosurgery
  Other : Advanced Techniques and Case Management
Source Genre: Journal
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Publ. Info: Elsevier
Pages: - Volume / Issue: 33 Sequence Number: 101796 Start / End Page: - Identifier: ISSN: 2214-7519
CoNE: https://pure.mpg.de/cone/journals/resource/2214-7519