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  Structural-and-dynamical similarity predicts compensatory brain areas driving the post-lesion functional recovery mechanism

Chakraborty, P., Saha, S., Deco, G., Banerjee, A., & Roy, D. (2023). Structural-and-dynamical similarity predicts compensatory brain areas driving the post-lesion functional recovery mechanism. Cerebral Cortex Communications, 4(3): tgad012. doi:10.1093/texcom/tgad012.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000D-79EF-F Version Permalink: https://hdl.handle.net/21.11116/0000-000D-9FA5-6
Genre: Journal Article

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 Creators:
Chakraborty, Priyanka1, Author
Saha, Suman1, Author
Deco, Gustavo2, 3, 4, 5, Author           
Banerjee, Arpan1, Author
Roy, Dipanjan1, Author
Affiliations:
1Cognitive Brain Dynamics Lab, National Brain Research Centre, Manesar, India, ou_persistent22              
2Computational Neuroscience Group, Department of Information and Communication Technologies, Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
3Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
4Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
5School of Psychological Sciences, Monash University, Melbourne, Australia, ou_persistent22              

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Free keywords: Virtual lesion; Structurally similar areas; Feedback inhibition control; Homeostasis; Dynamically similar areas
 Abstract: The focal lesion alters the excitation-inhibition (E-I) balance and normative healthy functional connectivity patterns, which may recover over time. One possible mechanism for the brain to counter the insult is global reshaping functional connectivity alterations. However, the operational principles by which this can be achieved remain unknown. We propose a novel equivalence principle based on structural and dynamic similarity analysis to predict whether specific compensatory areas initiate lost excitatory-inhibitory (E-I) regulation after lesion. We hypothesize that similar structural areas (SSAs) and dynamically similar areas (DSAs) corresponding to a lesioned site are the crucial dynamical units to restore lost homeostatic balance within the surviving cortical brain regions. SSAs and DSAs are independent measures, one based on structural similarity properties measured by Jaccard Index and the other based on post-lesion recovery time. We unravel the relationship between SSA and DSA by simulating a whole brain mean field model deployed on top of a virtually lesioned structural connectome from human neuroimaging data to characterize global brain dynamics and functional connectivity at the level of individual subjects. Our results suggest that wiring proximity and similarity are the two major guiding principles of compensation-related utilization of hemisphere (CRUH) in the post-lesion FC re-organization process.

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Language(s): eng - English
 Dates: 2023-06-302023-06-302023-07-052023-07-17
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1093/texcom/tgad012
Other: eCollection 2023
PMID: 37559936
PMC: PMC10409568
 Degree: -

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Project name : -
Grant ID : PDF/2021/000585
Funding program : -
Funding organization : SERB- DST, India
Project name : -
Grant ID : BT/MED- III/NBRC/Flagship/Flagship2019; BT/RLF/Re-entry/07/2014
Funding program : -
Funding organization : DBT, India
Project name : -
Grant ID : F.NO.K- 15015/42/2018/SP-V
Funding program : -
Funding organization : Ministry of Youth Affairs and Sports, India
Project name : -
Grant ID : SR/CSRI/21/2016
Funding program : -
Funding organization : DST, India

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Title: Cerebral Cortex Communications
Source Genre: Journal
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Publ. Info: Oxford : Oxford University Press
Pages: - Volume / Issue: 4 (3) Sequence Number: tgad012 Start / End Page: - Identifier: ISSN: 2632-7376
CoNE: https://pure.mpg.de/cone/journals/resource/2632-7376