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  A corollary discharge mediates saccade-related inhibition of single units in mnemonic structures of the human brain

Katz, C. N., Schjetnan, A. G., Patel, K., Barkley, V., Hoffman, K. L., Kalia, S. K., et al. (2022). A corollary discharge mediates saccade-related inhibition of single units in mnemonic structures of the human brain. Current Biology, 32(14), 3082-3094.e4. doi:10.1016/j.cub.2022.06.015.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000D-8E62-5 Version Permalink: https://hdl.handle.net/21.11116/0000-000D-8E63-4
Genre: Journal Article

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2023
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https://doi.org/10.1016/j.cub.2022.06.015 (Publisher version)
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 Creators:
Katz, Chaim N.1, Author
Schjetnan, Andrea G.P.1, Author
Patel, Kramay1, Author
Barkley, Victoria1, Author
Hoffman, Kari L.1, Author
Kalia, Suneil K.1, Author
Duncan, Katherine D.1, Author
Valiante, Taufik A.1, 2, Author
Affiliations:
1External Organizations, ou_persistent22              
2Max Planck - University of Toronto Centre for Neural Science and Technology, Max Planck Institute of Microstructure Physics, Max Planck Society, ou_3524333              

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 Abstract: Despite the critical link between visual exploration and memory, little is known about how neuronal activity in the human mesial temporal lobe (MTL) is modulated by saccades. Here, we characterize saccade-associated neuronal modulations, unit-by-unit, and contrast them to image onset and to occipital lobe neurons. We reveal evidence for a corollary discharge (CD)-like modulatory signal that accompanies saccades, inhibiting/exciting a unique population of broad-/narrow-spiking units, respectively, before and during saccades and with directional selectivity. These findings comport well with the timing, directional nature, and inhibitory circuit implementation of a CD. Additionally, by linking neuronal activity to event-related potentials (ERPs), which are directionally modulated following saccades, we recontextualize the ERP associated with saccades as a proxy for both the strength of inhibition and saccade direction, providing a mechanistic underpinning for the more commonly recorded saccade-related ERP in the human brain.

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 Dates: 2022-07-01
 Publication Status: Published online
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 Identifiers: DOI: 10.1016/j.cub.2022.06.015
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Title: Current Biology
  Abbreviation : Curr. Biol.
Source Genre: Journal
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Publ. Info: London, UK : Cell Press
Pages: - Volume / Issue: 32 (14) Sequence Number: - Start / End Page: 3082 - 3094.e4 Identifier: ISSN: 0960-9822
CoNE: https://pure.mpg.de/cone/journals/resource/954925579107