Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
  Preliminary Experience Using Magnetic Resonance Fingerprinting in Multiple Sclerosis

Ontaneda, D., Gulani, V., Deshmane, A., Shah, A., Guruprakash, D., Jiang, Y., et al. (2023). Preliminary Experience Using Magnetic Resonance Fingerprinting in Multiple Sclerosis. Multiple Sclerosis and Related Disorders, 79: 05024. doi:10.1016/j.msard.2023.105024.

Item is

Basisdaten

einblenden: ausblenden:
Genre: Zeitschriftenartikel

Externe Referenzen

einblenden:
ausblenden:
Beschreibung:
-
OA-Status:
Keine Angabe

Urheber

einblenden:
ausblenden:
 Urheber:
Ontaneda, D, Autor
Gulani, V, Autor
Deshmane, A1, Autor                 
Shah, A, Autor
Guruprakash, DK, Autor
Jiang, Y, Autor
Ma, D, Autor
Lee, J-C, Autor
Fisher, E, Autor
Rudick, RA, Autor
Raza, P, Autor
Kilbane, M, Autor
Cohen, JK, Autor
Sakaie, K, Autor
Lowe , MJ, Autor
Griswold, MA, Autor
Nakamura, K, Autor
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

Inhalt

einblenden:
ausblenden:
Schlagwörter: -
 Zusammenfassung: Background: In this cross sectional study, we used MRF to investigate tissue properties of normal-appearing white matter, gray matter, and lesions in relapsing remitting MS (n = 21), secondary progressive MS (n = 16) and healthy controls (n = 9). A FISP-based MRF sequence was used for acquisition, imaging time 5 min 15 s. MRF T1 and T2 relaxation times were measured from lesional tissue, normal-appearing frontal white matter, corpus callous, thalamus, and caudate. Differences between healthy controls and MS were examined using ANCOVA adjusted for age and sex. Spearman rank correlations were assessed between T1 and T2 relaxation times and clinical measures.
Objectives: To examine brain T1 and T2 values using magnetic resonance fingerprinting (MRF) in healthy controls and MS.
Methods: The subjects included 21 relapsing-remitting (RR) MS, 16 secondary progressive (SP) MS, and 9 age- and sex-matched HC without manifest neurological disease participating in a longitudinal MRI study. A 3T/ FISP-based MRF sequence was acquired. Regions of interest were drawn for lesions and normal appearing white matter. ANCOVA adjusted for age and sex were used to compare the groups with significance set at 0.05.
Results: A step-wise increase in T1 and T2 relaxation times was found between healthy controls, relapsing remitting MS, and secondary progressive MS. Significant differences were found in T1 and T2 between MS and healthy controls in the frontal normal-appearing white matter, corpus callosum, and thalamus (p < 0.04 for all). Significant differences in T1 and T2 between RR and SPMS were found in the frontal normal-appearing white matter and T2 lesions (p < 0.02 for all). T1 relaxation from the frontal normal-appearing white matter correlated with the Expanded Disability Status Scale [ρ = 0.62, p < 0.001], timed 25 foot walk (ρ = 0.45, p = 0.01), 9 hole peg test (ρ = 0.62, p < 0.001), and paced auditory serial addition test (ρ = -0.4, p = 0.01).
Conclusion: These results suggest that MRF may be a clinically feasible quantitative approach for characterizing tissue damage in MS.

Details

einblenden:
ausblenden:
Sprache(n):
 Datum: 2023-11
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1016/j.msard.2023.105024
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: Multiple Sclerosis and Related Disorders
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: 6 Band / Heft: 79 Artikelnummer: 05024 Start- / Endseite: - Identifikator: -