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  Diversity matters — extending sound intensity coding by inner hair cells via heterogeneous synapses

Moser, T., Karagulyan, N., Neef, J., & Jaime Tobón, L. M. (2023). Diversity matters — extending sound intensity coding by inner hair cells via heterogeneous synapses. The EMBO Journal, 42(23): e114587. doi:10.15252/embj.2023114587.

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moser-et-al-2023-diversity-matters-extending-sound-intensity-coding-by-inner-hair-cells-via-heterogeneous-synapses.pdf (Publisher version), 7MB
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Moser, Tobias1, Author           
Karagulyan, Nare1, Author           
Neef, Jakob1, Author           
Jaime Tobón, Lina María1, Author                 
Affiliations:
1Research Group of Synaptic Nanophysiology, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society, ou_3350139              

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 Abstract: Our sense of hearing enables the processing of stimuli that differ in sound pressure by more than six orders of magnitude. How to process a wide range of stimulus intensities with temporal precision is an enigmatic phenomenon of the auditory system. Downstream of dynamic range compression by active cochlear micromechanics, the inner hair cells (IHCs) cover the full intensity range of sound input. Yet, the firing rate in each of their postsynaptic spiral ganglion neurons (SGNs) encodes only a fraction of it. As a population, spiral ganglion neurons with their respective individual coding fractions cover the entire audible range. How such “dynamic range fractionation” arises is a topic of current research and the focus of this review. Here, we discuss mechanisms for generating the diverse functional properties of SGNs and formulate testable hypotheses. We postulate that an interplay of synaptic heterogeneity, molecularly distinct subtypes of SGNs, and efferent modulation serves the neural decomposition of sound information and thus contributes to a population code for sound intensity.

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Language(s): eng - English
 Dates: 2023-10-062023-12-01
 Publication Status: Issued
 Pages: -
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 Rev. Type: Peer
 Identifiers: DOI: 10.15252/embj.2023114587
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Project name : LMJT is a recipient of the Erwin Neher Fellowship and TM is a Max‐Planck Fellow at the Max Planck Institute for Multidisciplinary Sciences. Work of the authors was supported by research grants from the Deutsche Forschungsgemeinschaft (DFG) through the CRC 889 project A02 and under Germany's Excellence Strategy—EXC 2067/1‐390729940 to TM, as well as by the European Union (ERC, “DynaHear”, grant agreement No. 101054467, to TM). In addition, this research is supported by Fondation Pour l'Audition (FPA RD‐2020‐10) to TM. The funders had no influence in literature selection for interpretation as well as writing of the manuscript. Views and opinions expressed are those of the authors only and do not necessarily reflect those of the European Union, the European Research Council Executive Agency, or the other funders. Neither the European Union nor the granting authority or other funders can be held responsible for them. Open Access funding enabled and organized by Projekt DEAL.
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Project name : DynaHear
Grant ID : 101054467
Funding program : Horizon 2020 (H2020)
Funding organization : European Commission (EC)

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Title: The EMBO Journal
  Other : EMBO J.
Source Genre: Journal
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Publ. Info: Nature Publishing Group
Pages: - Volume / Issue: 42 (23) Sequence Number: e114587 Start / End Page: - Identifier: ISSN: 0261-4189
CoNE: https://pure.mpg.de/cone/journals/resource/954925497061_1