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  The regional variation of laminar thickness in the human isocortex is related to cortical hierarchy and interregional connectivity

Saberi, A., Paquola, C., Wagstyl, K., Hettwer, M., Bernhardt, B. C., Eickhoff, S. B., et al. (2023). The regional variation of laminar thickness in the human isocortex is related to cortical hierarchy and interregional connectivity. PLoS Biology, 21(11): e3002365. doi:10.1371/journal.pbio.3002365.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000D-EA0B-0 Version Permalink: https://hdl.handle.net/21.11116/0000-000D-FF22-E
Genre: Journal Article

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 Creators:
Saberi, Amin1, 2, 3, Author                 
Paquola, Casey2, Author
Wagstyl, Konrad4, Author
Hettwer, Meike1, 2, 3, 5, Author           
Bernhardt, Boris C.6, Author
Eickhoff, Simon B.2, 3, Author
Valk, Sofie L.1, 2, 3, Author                 
Affiliations:
1Otto Hahn Group Cognitive Neurogenetics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3222264              
2Institute of Neuroscience and Medicine, Research Center Jülich, Germany, ou_persistent22              
3Institute of Systems Neuroscience, University Hospital Düsseldorf, Germany, ou_persistent22              
4Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom, ou_persistent22              
5Max Planck School of Cognition, Max Planck Schools, Max Planck Society, ou_3473635              
6Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, QC, Canada, ou_persistent22              

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 Abstract: The human isocortex consists of tangentially organized layers with unique cytoarchitectural properties. These layers show spatial variations in thickness and cytoarchitecture across the neocortex, which is thought to support function through enabling targeted corticocortical connections. Here, leveraging maps of the 6 cortical layers based on 3D human brain histology, we aimed to quantitatively characterize the systematic covariation of laminar structure in the cortex and its functional consequences. After correcting for the effect of cortical curvature, we identified a spatial pattern of changes in laminar thickness covariance from lateral frontal to posterior occipital regions, which differentiated the dominance of infra- versus supragranular layer thickness. Corresponding to the laminar regularities of cortical connections along cortical hierarchy, the infragranular-dominant pattern of laminar thickness was associated with higher hierarchical positions of regions, mapped based on resting-state effective connectivity in humans and tract-tracing of structural connections in macaques. Moreover, we show that regions with similar laminar thickness patterns have a higher likelihood of structural connections and strength of functional connections. In sum, here, we characterize the organization of laminar thickness in the human isocortex and its association with cortico-cortical connectivity, illustrating how laminar organization may provide a foundational principle of cortical function.

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Language(s): eng - English
 Dates: 2023-03-282023-10-062023-11-09
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1371/journal.pbio.3002365
Other: eCollection 2023
PMID: 37943873
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Project name : -
Grant ID : InterLabs-0015
Funding program : -
Funding organization : Helmholtz Association
Project name : -
Grant ID : -
Funding program : -
Funding organization : Canada First Research Excellence Fund (CFREF)
Project name : Otto Hahn award
Grant ID : -
Funding program : -
Funding organization : Max Planck Society
Project name : -
Grant ID : 215901/Z/19/Z
Funding program : -
Funding organization : Wellcome Trust
Project name : -
Grant ID : -
Funding program : -
Funding organization : German Federal Ministry of Education and Research (BMBF)
Project name : -
Grant ID : NI17-039
Funding program : -
Funding organization : SickKids Foundation
Project name : -
Grant ID : Discovery-1304413
Funding program : -
Funding organization : National Sciences and Engineering Research Council of Canada (NSERC)
Project name : -
Grant ID : FDN-154298
Funding program : -
Funding organization : Canadian Institutes of Health Research (CIHR)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Azrieli Center for Autism Research (ACAR)

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Title: PLoS Biology
  Other : PLoS Biol.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: San Francisco, California, US : Public Library of Science
Pages: - Volume / Issue: 21 (11) Sequence Number: e3002365 Start / End Page: - Identifier: ISSN: 1544-9173
CoNE: https://pure.mpg.de/cone/journals/resource/111056649444170