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  Longitudinal analysis of the gut microbiome in adolescent patients with anorexia nervosa: microbiome-related factors associated with clinical outcome

Andreani, N. A., Sharma, A., Dahmen, B., Specht, H. E., Mannig, N., Ruan, V., et al. (2024). Longitudinal analysis of the gut microbiome in adolescent patients with anorexia nervosa: microbiome-related factors associated with clinical outcome. Gut Microbes, 16(1): 2304158. doi:10.1080/19490976.2024.2304158.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000E-6670-1 Version Permalink: https://hdl.handle.net/21.11116/0000-000E-6671-0
Genre: Journal Article

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 Creators:
Andreani, Nadia Andrea1, Author                 
Sharma, Arunabh, Author
Dahmen, Brigitte, Author
Specht, Hannah E., Author
Mannig, Nina, Author
Ruan, Vanessa, Author
Keller, Lara, Author
Baines, John F.1, Author                 
Herpertz-Dahlmann, Beate, Author
Dempfle, Astrid, Author
Seitz, Jochen, Author
Affiliations:
1Guest Group Evolutionary Medicine (Baines), Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_3371474              

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Free keywords: Microbiota; anorexia nervosa; eating disorder; gut-brain axis; adolescents; longitudinal study; weight- recovered patients; low- weight patients; illness duration; long-term follow- up
 Abstract: There is mounting evidence regarding the role of gut microbiota in anorexia nervosa (AN). Previous studies have reported that patients with AN show dysbiosis compared to healthy controls (HCs); however, the underlying mechanisms are unclear, and data on influencing factors and longitudinal course of microbiome changes are scarce. Here, we present longitudinal data of 57 adolescent inpatients diagnosed with AN at up to nine time points (including a 1-year follow-up examination) and compare these to up to six time points in 34 HCs. 16S rRNA gene sequencing was used to investigate the microbiome composition of fecal samples, and data on food intake, weight change, hormonal recovery (leptin levels), and clinical outcomes were recorded. Differences in microbiome composition compared to HCs were greatest during acute starvation and in the low-weight group, while diminishing with weight gain and especially weight recovery at the 1-year follow-up. Illness duration and prior weight loss were strongly associated with microbiome composition at hospital admission, whereas microbial changes during treatment were associated with kilocalories consumed, weight gain, and hormonal recovery. The microbiome at admission was prognostic for hospital readmission, and a higher abundance of Sutterella was associated with a higher body weight at the 1-year follow-up. Identifying these clinically important factors further underlines the potential relevance of gut microbial changes and may help elucidate the underlying pathophysiology of gut-brain interactions in AN. The characterization of prognostically relevant taxa could be useful to stratify patients at admission and to potentially identify candidate taxa for future supplementation studies aimed at improving AN treatment.

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Language(s): eng - English
 Dates: 2023-12-192023-07-052024-01-082024-01-312024
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1080/19490976.2024.2304158
 Degree: -

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Project name : ERA-NET Neuron program
Grant ID : 01EW1906A-01EW1906B
Funding program : Horizon 2020 (H2020)
Funding organization : European Commission (EC)
Project name : The role of the intestinal microbiome regarding prognosis and therapy in adolescent Anorexia nervosa – clinical and translational analyses
Grant ID : SE 2787/3-1
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft
Project name : The microbiome as a therapeutic target in inflammatory bowel diseases
Grant ID : DE1614/4-1
Funding program : Research Unit FOR5042
Funding organization : Deutsche Forschungsgemeinschaft
Project name : Precision Medicine in Chronic 688 Inflammation PMI
Grant ID : E×C2167
Funding program : Excellence Cluster
Funding organization : Deutsche Forschungsgemeinschaft

Source 1

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Title: Gut Microbes
Source Genre: Journal
 Creator(s):
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Publ. Info: London : Taylor & Francis
Pages: - Volume / Issue: 16 (1) Sequence Number: 2304158 Start / End Page: - Identifier: Other: http://www.tandfonline.com/loi/kgmi20
Other: http://www.sherpa.ac.uk/romeo/issn/1949-0976/
Other: https://zdb-katalog.de/list.xhtml?t=gut+microbes
Other: http://ezb.uni-regensburg.de/searchres.phtml?bibid=MPG&colors=7&lang=de&jq_type1=QS&jq_term1=gut+microbes
Other: 1949-0984
CoNE: https://pure.mpg.de/cone/journals/resource/1949-0976