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  Structure and function of the hippocampal CA3 module

Sammons, R. P., Vezir, M., Moreno-Velasquez, L., Cano, G., Orlando, M., Sievers, M., et al. (2024). Structure and function of the hippocampal CA3 module. PNAS, 121(6): e2312281120. doi:10.1073/pnas.2312281120.

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Sammons_2024_StructureAndFunction.pdf (Publisher version), 9MB
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2024
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Copyright © 2024 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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 Creators:
Sammons, Rosanna P., Author
Vezir, Mourat1, 2, Author
Moreno-Velasquez, Laura, Author
Cano, Gaspar, Author
Orlando, Marta, Author
Sievers, Meike, Author
Grasso, Eleonora1, 2, Author
Metodieva, Verjinia D., Author
Kempter, Richard, Author
Schmidt, Helene1, 2, Author                 
Schmitz, Dietmar, Author
Affiliations:
1Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society, ou_2074314              
2Schmidt Lab, Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society, Deutschordenstraße 46, 60528 Frankfurt, DE, ou_3381235              

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Free keywords: CONNECTOMICS CA3 ELECTRON MICROSCOPY PATTERN COMPLETION MEMORY
 Abstract: The hippocampal formation is crucial for learning and memory, with submodule CA3 thought to be the substrate of pattern completion. However, the underlying synaptic and computational mechanisms of this network are not well understood. Here, we perform circuit reconstruction of a CA3 module using three dimensional (3D) electron microscopy data and combine this with functional connectivity recordings and computational simulations to determine possible CA3 network mechanisms. Direct measurements of connectivity schemes with both physiological measurements and structural 3D EM revealed a high connectivity rate, multi-fold higher than previously assumed. Mathematical modelling indicated that such CA3 networks can robustly generate pattern completion and replay memory sequences. In conclusion, our data demonstrate that the connectivity scheme of the hippocampal submodule is well suited for efficient memory storage and retrieval.

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 Dates: 2024-01-302024-02-06
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1073/pnas.2312281120
 Degree: -

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Title: PNAS
  Other : Proceedings of the National Academy of Sciences of the United States of America
  Other : Proceedings of the National Academy of Sciences of the USA
  Abbreviation : Proc. Natl. Acad. Sci. U. S. A.
Source Genre: Journal
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Publ. Info: Washington, D.C. : National Academy of Sciences
Pages: - Volume / Issue: 121 (6) Sequence Number: e2312281120 Start / End Page: - Identifier: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230