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  The flattening of spacetime hierarchy of the DMT brain state is characterised by harmonic decomposition of spacetime (HADES) framework

Vohryzek, J., Cabral, J., Timmermann, C., Atasoy, S., Roseman, L., Nutt, D. J., et al. (2024). The flattening of spacetime hierarchy of the DMT brain state is characterised by harmonic decomposition of spacetime (HADES) framework. National Science Review, 11(5): nwae124. doi:10.1093/nsr/nwae124.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-000F-2E9C-F Versions-Permalink: https://hdl.handle.net/21.11116/0000-000F-5474-0
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 Urheber:
Vohryzek, Jakub1, 2, 3, 4, Autor
Cabral, Joana1, 5, 6, Autor
Timmermann, Christopher7, Autor
Atasoy, Selen1, 2, Autor
Roseman, Leor7, Autor
Nutt, David J.7, Autor
Carhart-Harris, Robin L.7, 8, Autor
Deco, Gustavo4, 9, 10, 11, Autor           
Kringelbach, Morten L.1, 2, 3, Autor
Affiliations:
1Centre for Eudaimonia and Human Flourishing, University of Oxford, United Kingdom, ou_persistent22              
2Department of Psychiatry, University of Oxford, United Kingdom, ou_persistent22              
3Center for Music in the Brain, Aarhus University, Denmark, ou_persistent22              
4Computational Neuroscience Group, Department of Information and Communication Technologies, Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
5ICVS - Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga, Portugal, ou_persistent22              
6ICVS/3B’s - PT Government Associate Laboratory, Braga, Portugal, ou_persistent22              
7Psychedelic Research Group, Division of Brain Sciences, Faculty of Medicine, Imperial College London, United Kingdom, ou_persistent22              
8Departments of Neurology and Psychiatry, University of California, San Francisco, CA, USA, ou_persistent22              
9Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
10Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
11School of Psychological Sciences, Monash University, Melbourne, Australia, ou_persistent22              

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Schlagwörter: Spatiotemporal brain dynamics; DMT; Harmonic modes
 Zusammenfassung: The human brain is a complex system, whose activity exhibits flexible and continuous reorganisation across space and time. The decomposition of whole-brain recordings into harmonic modes has revealed a repertoire of gradient-like activity patterns associated with distinct brain functions. However, the way these activity patterns are expressed over time with their changes in various brain states remains unclear. Here, we investigate healthy participants taking the serotonergic psychedelic N, N-Dimethyltryptamine (DMT) with the Harmonic Decomposition of Spacetime (HADES) framework that can characterise how different harmonic modes defined in space are expressed over time. HADES demonstrates significant decreases in contributions across most low-frequency harmonic modes in the DMT-induced brain state. When normalizing the contributions by condition (DMT and non-DMT), we detect a decrease specifically in the second functional harmonic, which represents the uni- to transmodal functional hierarchy of the brain, supporting the leading hypothesis that functional hierarchy is changed in psychedelics. Moreover, HADES’ dynamic spacetime measures of fractional occupancy, life time and latent space provide a precise description of the significant changes of the spacetime hierarchical organization of brain activity in the psychedelic state.

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Sprache(n): eng - English
 Datum: 2024-04-042024-05
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1093/nsr/nwae124
Anderer: eCollection 2024
PMID: 38778818
PMC: PMC11110867
 Art des Abschluß: -

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Projektinformation

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Projektname : -
Grant ID : 101017716
Förderprogramm : FET Proactive project Neurotwin
Förderorganisation : European Union
Projektname : -
Grant ID : 615539
Förderprogramm : -
Förderorganisation : European Research Council (ERC)
Projektname : -
Grant ID : DNRF117
Förderprogramm : -
Förderorganisation : Danish National Research Foundation (DNRF)
Projektname : -
Grant ID : LCF/BQ/PR22/11920014
Förderprogramm : -
Förderorganisation : ‘la Caixa’ Foundation
Projektname : -
Grant ID : UIDB/50026/2020; UIDP/50026/2020
Förderprogramm : -
Förderorganisation : Portuguese Foundation for Science and Technology
Projektname : -
Grant ID : PSI2016-75688-P
Förderprogramm : -
Förderorganisation : Spanish Research Project
Projektname : -
Grant ID : 720270; 785907
Förderprogramm : Horizon 2020
Förderorganisation : European Union
Projektname : -
Grant ID : 2017 SGR 1545
Förderprogramm : -
Förderorganisation : Catalan Agency for Management of University and Research Grants

Quelle 1

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Titel: National Science Review
  Andere : NSR / Chinese Academy of Sciences
  Kurztitel : NSR
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Oxford : Oxford University Press
Seiten: - Band / Heft: 11 (5) Artikelnummer: nwae124 Start- / Endseite: - Identifikator: ISSN: 2095-5138
CoNE: https://pure.mpg.de/cone/journals/resource/2095-5138