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  The flattening of spacetime hierarchy of the DMT brain state is characterised by harmonic decomposition of spacetime (HADES) framework

Vohryzek, J., Cabral, J., Timmermann, C., Atasoy, S., Roseman, L., Nutt, D. J., Carhart-Harris, R. L., Deco, G., & Kringelbach, M. L. (2024). The flattening of spacetime hierarchy of the DMT brain state is characterised by harmonic decomposition of spacetime (HADES) framework. National Science Review, 11(5):. doi:10.1093/nsr/nwae124.

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-000F-2E9C-F 版のパーマリンク: https://hdl.handle.net/21.11116/0000-000F-5474-0
資料種別: 学術論文

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作成者

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 作成者:
Vohryzek, Jakub1, 2, 3, 4, 著者
Cabral, Joana1, 5, 6, 著者
Timmermann, Christopher7, 著者
Atasoy, Selen1, 2, 著者
Roseman, Leor7, 著者
Nutt, David J.7, 著者
Carhart-Harris, Robin L.7, 8, 著者
Deco, Gustavo4, 9, 10, 11, 著者           
Kringelbach, Morten L.1, 2, 3, 著者
所属:
1Centre for Eudaimonia and Human Flourishing, University of Oxford, United Kingdom, ou_persistent22              
2Department of Psychiatry, University of Oxford, United Kingdom, ou_persistent22              
3Center for Music in the Brain, Aarhus University, Denmark, ou_persistent22              
4Computational Neuroscience Group, Department of Information and Communication Technologies, Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
5ICVS - Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga, Portugal, ou_persistent22              
6ICVS/3B’s - PT Government Associate Laboratory, Braga, Portugal, ou_persistent22              
7Psychedelic Research Group, Division of Brain Sciences, Faculty of Medicine, Imperial College London, United Kingdom, ou_persistent22              
8Departments of Neurology and Psychiatry, University of California, San Francisco, CA, USA, ou_persistent22              
9Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
10Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
11School of Psychological Sciences, Monash University, Melbourne, Australia, ou_persistent22              

内容説明

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キーワード: Spatiotemporal brain dynamics; DMT; Harmonic modes
 要旨: The human brain is a complex system, whose activity exhibits flexible and continuous reorganisation across space and time. The decomposition of whole-brain recordings into harmonic modes has revealed a repertoire of gradient-like activity patterns associated with distinct brain functions. However, the way these activity patterns are expressed over time with their changes in various brain states remains unclear. Here, we investigate healthy participants taking the serotonergic psychedelic N, N-Dimethyltryptamine (DMT) with the Harmonic Decomposition of Spacetime (HADES) framework that can characterise how different harmonic modes defined in space are expressed over time. HADES demonstrates significant decreases in contributions across most low-frequency harmonic modes in the DMT-induced brain state. When normalizing the contributions by condition (DMT and non-DMT), we detect a decrease specifically in the second functional harmonic, which represents the uni- to transmodal functional hierarchy of the brain, supporting the leading hypothesis that functional hierarchy is changed in psychedelics. Moreover, HADES’ dynamic spacetime measures of fractional occupancy, life time and latent space provide a precise description of the significant changes of the spacetime hierarchical organization of brain activity in the psychedelic state.

資料詳細

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言語: eng - English
 日付: 2024-04-042024-05
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: -
 識別子（DOI, ISBNなど）: DOI: 10.1093/nsr/nwae124
その他: eCollection 2024
PMID: 38778818
PMC: PMC11110867
 学位: -

関連イベント

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Project information

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Project name : -
Grant ID : 101017716
Funding program : FET Proactive project Neurotwin
Funding organization : European Union
Project name : -
Grant ID : 615539
Funding program : -
Funding organization : European Research Council (ERC)
Project name : -
Grant ID : DNRF117
Funding program : -
Funding organization : Danish National Research Foundation (DNRF)
Project name : -
Grant ID : LCF/BQ/PR22/11920014
Funding program : -
Funding organization : ‘la Caixa’ Foundation
Project name : -
Grant ID : UIDB/50026/2020; UIDP/50026/2020
Funding program : -
Funding organization : Portuguese Foundation for Science and Technology
Project name : -
Grant ID : PSI2016-75688-P
Funding program : -
Funding organization : Spanish Research Project
Project name : -
Grant ID : 720270; 785907
Funding program : Horizon 2020
Funding organization : European Union
Project name : -
Grant ID : 2017 SGR 1545
Funding program : -
Funding organization : Catalan Agency for Management of University and Research Grants

出版物 1

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出版物名: National Science Review
  その他 : NSR / Chinese Academy of Sciences
  省略形 : NSR
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: Oxford : Oxford University Press
ページ: - 巻号: 11 (5) 通巻号: nwae124 開始・終了ページ: - 識別子（ISBN, ISSN, DOIなど）: ISSN: 2095-5138
CoNE: https://pure.mpg.de/cone/journals/resource/2095-5138