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  Combining multi-echo and phase cycling in bSSFP acquisition to improve whole-brain deuterium metabolic imaging at 9.4 T

Valsala, P., Pohmann, R., Heule, R., Avdievich, N., Engelmann, J., Kuebler, L., et al. (2024). Combining multi-echo and phase cycling in bSSFP acquisition to improve whole-brain deuterium metabolic imaging at 9.4 T. Poster presented at ISMRM & ISMRT Annual Meeting & Exhibition 2024, Singapore.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000F-3959-E Version Permalink: https://hdl.handle.net/21.11116/0000-000F-41E5-5
Genre: Poster

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https://www.ismrm.org/24/docs/24ToC.pdf (Abstract)
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 Creators:
Valsala, PI1, Author                 
Pohmann, R1, Author                 
Heule, R2, Author                 
Avdievich, N1, Author                 
Engelmann, J1, Author           
Kuebler, L, Author
Martins, AF, Author
Scheffler, K1, Author                 
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Institutional Guests, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_3505519              

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 Abstract: Motivation: Deuterium metabolic imaging could significantly impact the field of neuro-oncology by providing clinical quantitative metabolic information. Goal(s): To improve the spatial resolution of human deuterium metabolic imaging at 9.4 T. Approach: We performed phantom and in vivo experiments with oral intake of deuterated glucose using multi- echo phase-cycled bSSFP acquisitions. The results were compared with a standard 3D spectroscopy sequence. Results: We achieved higher spatial resolution compared to a 3D spectroscopy sequence. Phase cycling improved the reliability of the metabolite quantification especially in the large off-resonance and low SNR regimes. Impact: We present an improved whole-brain dynamic deuterium metabolic imaging strategy at 9.4 T using bSSFP with multiple echoes and phase cycling. The efficacy of this method is validated with phantom and in vivo experiments along with standard spectroscopy measurements.

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 Dates: 2024-05
 Publication Status: Published online
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Title: ISMRM & ISMRT Annual Meeting & Exhibition 2024
Place of Event: Singapore
Start-/End Date: 2024-05-04 - 2024-05-09

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Title: ISMRM & ISMRT Annual Meeting & Exhibition 2024
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 0224 Start / End Page: 158 Identifier: -