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Poster

Combining multi-echo and phase cycling in bSSFP acquisition to improve whole-brain deuterium metabolic imaging at 9.4 T

MPS-Authors
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Valsala,  PI       
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Pohmann,  R       
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Heule,  R       
Institutional Guests, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Avdievich,  N       
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Engelmann,  J
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Scheffler,  K       
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

External Resource

https://www.ismrm.org/24/docs/24ToC.pdf
(Abstract)

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Citation

Valsala, P., Pohmann, R., Heule, R., Avdievich, N., Engelmann, J., Kuebler, L., et al. (2024). Combining multi-echo and phase cycling in bSSFP acquisition to improve whole-brain deuterium metabolic imaging at 9.4 T. Poster presented at ISMRM & ISMRT Annual Meeting & Exhibition 2024, Singapore.


Cite as: https://hdl.handle.net/21.11116/0000-000F-3959-E
Abstract
Motivation: Deuterium metabolic imaging could significantly impact the field of neuro-oncology by providing clinical quantitative metabolic information. Goal(s): To improve the spatial resolution of human deuterium metabolic imaging at 9.4 T. Approach: We performed phantom and in vivo experiments with oral intake of deuterated glucose using multi- echo phase-cycled bSSFP acquisitions. The results were compared with a standard 3D spectroscopy sequence. Results: We achieved higher spatial resolution compared to a 3D spectroscopy sequence. Phase cycling improved the reliability of the metabolite quantification especially in the large off-resonance and low SNR regimes. Impact: We present an improved whole-brain dynamic deuterium metabolic imaging strategy at 9.4 T using bSSFP with multiple echoes and phase cycling. The efficacy of this method is validated with phantom and in vivo experiments along with standard spectroscopy measurements.