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  'Genetic variants for head size share genes and pathways with cancer

Knol, M. J., Poot, R. A., Evans, T. E., Satizabal, C. L., Mishra, A., Sargurupremraj, M., et al. (2024). 'Genetic variants for head size share genes and pathways with cancer. Cell Reports Medicine. Advance online publication. doi:10.1016/j.xcrm.2024.101529.

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Knol_etal_2024_genetic variants for head size....pdf (Verlagsversion), 4MB
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2024
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© 2024 The Author(s). Published by Elsevier Inc This is an open access article distributed under the terms of the Creative Commons CC-BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You are not required to obtain permission to reuse this article.

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 Urheber:
Knol, Maria J., Autor
Poot, Raymond A., Autor
Evans, Tavia E., Autor
Satizabal, Claudia L., Autor
Mishra, Aniket, Autor
Sargurupremraj, Muralidharan, Autor
Van der Auwera, Sandra, Autor
Duperron, Marie-Gabrielle, Autor
Jian, Xueqiu, Autor
Hostettler, Isabel C., Autor
Van Dam-Nolen, Dianne H. K., Autor
Lamballais, Sander, Autor
Pawlak, Mikolaj A., Autor
Lewis, Cora E., Autor
Carrion Castillo, Amaia1, Autor           
Van Erp, Theo G. M., Autor
Reinbold, Celine S., Autor
Shin, Jean, Autor
Sholz, Markus, Autor
Håberg, Asta K., Autor
Kämpe, Anders, AutorLi, Gloria H. Y., AutorAtkins, Joshua R., AutorHsu, Fang-Chi, AutorAmod, Alyssa R., AutorLam, Max, AutorTsuchida, Ami, AutorTeunissen, Mariël W. A., AutorAygün, Nil, AutorPatel, Yash, AutorLiang, Dan, AutorBeiser, Alexa S., AutorBeyer, Frauke, AutorBis, Joshua C., AutorBos, Daniel, AutorBryan, R. Nick, AutorBülow, Robin, AutorCaspers, Svenja, AutorCatheline, Gwenaëlle , AutorCecil, Charlotte A. M., AutorDalvie, Shareefa, AutorFreedman, Barry I., AutorFriedrich, Nele, AutorGreen, Melissa J., AutorHaworth, Simon, AutorHelmer, Catherine, AutorHoffmann, Per, AutorHomuth, Georg, AutorIkram, M. Kamran, AutorJack, Clifford R., AutorJahanshad, Neda, AutorJockwitz, Christiane, AutorKamatani, Yoichiro, AutorKnodt, Annchen R., AutorLi, Shuo, AutorLim, Keane, AutorLongstreth, W. T. , AutorMacciardi, Fabio, AutorThe Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, Autor              The Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium, Autor              Mäkitie, Outi, AutorMazoyer, Bernard, AutorMedland, Sarah E., AutorMiyamoto, Susumu, AutorMoebus, Susanne, AutorMosley, Thomas H., AutorMuetzel, Ryan, AutorMühleisen, Thomas W., AutorNagata, Manabu, AutorNakahara, Soichiro, AutorPalmer, Nicholette D., AutorPausova, Zdenka, AutorPreda, Adrian, AutorQuidé, Yann, AutorReay, William R., AutorRoshchupkin, Gennady V., AutorSchmidt, Reinhold, AutorSchreiner, Pamela J., AutorSetoh, Kazuya, AutorShapland, Chin Yang, Autor           Sidney, Stephen, AutorSt Pourcain, Beate1, 2, Autor           Stein, Jason L., AutorTabara, Yasuharu, AutorTeumer, Alexander, AutorUhlmann, Anne, AutorVan de Lught, Aad, AutorVernooij, Meike W., AutorWerring, David J., AutorWindham, B. Gwen, AutorWitte, A. Veronica, AutorWittfeld, Katharina, AutorYang, Qiong, AutorYoshida, Kazumichi, AutorBrunner, Han G., AutorLe Grand, Quentin, AutorSim, Kang, AutorStein, Dan J., AutorBowden, Donald W., AutorCairns, Murray J., AutorHariri, Ahmad R., AutorCheung, Ching-Lung, AutorAndersson, Sture, AutorVillringer, Arno, AutorPaus, Tomas, AutorChichon, Sven, AutorCalhoun, Vince D., AutorCrivello, Fabrice, AutorLauner, Lenore J., AutorWhite, Tonya, AutorKoudstaal, Peter J., AutorHoulden, Henry, AutorFornage, Myriam, AutorMatsuda, Fumihiko, AutorGrabe, Hans J., AutorIkram, M. Arfan, AutorDebette, Stephanie, AutorThompson, Paul M., AutorSeshadri, Sudha, AutorAdams, Hieab H. H., Autor mehr..
Affiliations:
1Language and Genetics Department, MPI for Psycholinguistics, Max Planck Society, Nijmegen, NL, ou_792549              
2Population genetics of human communication, MPI for Psycholinguistics, Max Planck Society, ou_2579694              

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 Zusammenfassung: The size of the human head is highly heritable, but genetic drivers of its variation within the general population remain unmapped. We perform a genome-wide association study on head size (N = 80,890) and identify 67 genetic loci, of which 50 are novel. Neuroimaging studies show that 17 variants affect specific brain areas, but most have widespread effects. Gene set enrichment is observed for various cancers and the p53, Wnt, and ErbB signaling pathways. Genes harboring lead variants are enriched for macrocephaly syndrome genes (37-fold) and high-fidelity cancer genes (9-fold), which is not seen for human height variants. Head size variants are also near genes preferentially expressed in intermediate progenitor cells, neural cells linked to evolutionary brain expansion. Our results indicate that genes regulating early brain and cranial growth incline to neoplasia later in life, irrespective of height. This warrants investigation of clinical implications of the link between head size and cancer.

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Sprache(n): eng - English
 Datum: 20242024-05-03
 Publikationsstatus: Online veröffentlicht
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/j.xcrm.2024.101529
 Art des Abschluß: -

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Titel: Cell Reports Medicine. Advance online publication
  Kurztitel : CELL REP MED
Genre der Quelle: Zeitschrift
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Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: - Artikelnummer: - Start- / Endseite: - Identifikator: CoNE: https://pure.mpg.de/cone/journals/resource/2666-3791