Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT

Freigegeben

Zeitschriftenartikel

'Genetic variants for head size share genes and pathways with cancer

MPG-Autoren
/persons/resource/persons71726

Carrion Castillo,  Amaia
Language and Genetics Department, MPI for Psycholinguistics, Max Planck Society, Nijmegen, NL;

/persons/resource/persons180748

St Pourcain,  Beate
Language and Genetics Department, MPI for Psycholinguistics, Max Planck Society, Nijmegen, NL;
Population genetics of human communication, MPI for Psycholinguistics, Max Planck Society;

Externe Ressourcen

link to supplemental information
(Ergänzendes Material)

Volltexte (beschränkter Zugriff)
Für Ihren IP-Bereich sind aktuell keine Volltexte freigegeben.
Volltexte (frei zugänglich)
Ergänzendes Material (frei zugänglich)
Es sind keine frei zugänglichen Ergänzenden Materialien verfügbar
Zitation

Knol, M. J., Poot, R. A., Evans, T. E., Satizabal, C. L., Mishra, A., Sargurupremraj, M., et al. (2024). 'Genetic variants for head size share genes and pathways with cancer. Cell Reports Medicine. Advance online publication. doi:10.1016/j.xcrm.2024.101529.


Zitierlink: https://hdl.handle.net/21.11116/0000-000F-3BE6-C
Zusammenfassung
The size of the human head is highly heritable, but genetic drivers of its variation within the general population remain unmapped. We perform a genome-wide association study on head size (N = 80,890) and identify 67 genetic loci, of which 50 are novel. Neuroimaging studies show that 17 variants affect specific brain areas, but most have widespread effects. Gene set enrichment is observed for various cancers and the p53, Wnt, and ErbB signaling pathways. Genes harboring lead variants are enriched for macrocephaly syndrome genes (37-fold) and high-fidelity cancer genes (9-fold), which is not seen for human height variants. Head size variants are also near genes preferentially expressed in intermediate progenitor cells, neural cells linked to evolutionary brain expansion. Our results indicate that genes regulating early brain and cranial growth incline to neoplasia later in life, irrespective of height. This warrants investigation of clinical implications of the link between head size and cancer.