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  Body size interacts with the structure of the central nervous system: A multi-center in vivo neuroimaging study

Labounek, R., Bondy, M. T., Paulson, A. L., Bédard, S., Abramovic, M., Alonso-Ortiz, E., et al. (2024). Body size interacts with the structure of the central nervous system: A multi-center in vivo neuroimaging study. bioRxiv. doi:10.1101/2024.04.29.591421.

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Labounek, René, Autor
Bondy, Monica T., Autor
Paulson, Amy L., Autor
Bédard, Sandrine, Autor
Abramovic, Mihael, Autor
Alonso-Ortiz, Eva, Autor
Atcheson, Nicole T, Autor
Barlow, Laura R., Autor
Barry, Robert L., Autor
Barth, Markus, Autor
Battiston, Marco, Autor
Büchel, Christian, Autor
Budde, Matthew D., Autor
Callot, Virginie, Autor
Combes, Anna, Autor
Leener, Benjamin De, Autor
Descoteaux, Maxime, Autor
de Sousa, Paulo Loureiro, Autor
Dostál, Marek, Autor
Doyon, Julien, Autor
Dvorak, Adam V., AutorEippert, Falk1, Autor                 Epperson, Karla R., AutorEpperson, Kevin S., AutorFreund, Patrick, AutorFinsterbusch, Jürgen, AutorFoias, Alexandru, AutorFratini, Michela, AutorFukunaga, Issei, AutorWheeler-Kingshott, Claudia A. M. Gandini, AutorGermani, GianCarlo, AutorGilbert, Guillaume, AutorGiove, Federico, AutorGrussu, Francesco, AutorHagiwara, Akifumi, AutorHenry, Pierre-Gilles, AutorHorák, Tomáš, AutorHori, Masaaki, AutorJoers, James M., AutorKamiya, Kouhei, AutorKarbasforoushan, Haleh, AutorKeřkovský, Miloš, AutorKhatibi, Ali, AutorKim, Joo-won, AutorKinany, Nawal, AutorKitzler, Hagen, AutorKolind, Shannon, AutorKong, Yazhuo, AutorKudlička, Petr, AutorKuntke, Paul, AutorKurniawan, Nyoman D., AutorKusmia, Slawomir, AutorLaganà, Maria Marcella, AutorLaule, Cornelia, AutorLaw, Christine S. W., AutorLeutritz, Tobias2, Autor                 Liu, Yaou, AutorLlufriu, Sara, AutorMackey, Sean, AutorMartin, Allan R., AutorMartinez-Heras, Eloy, AutorMattera, Loan, AutorO’Grady, Kristin P., AutorPapinutto, Nico, AutorPapp, Daniel, AutorPareto, Deborah, AutorParrish, Todd B., AutorPichiecchio, Anna, AutorPrados, Ferran, AutorRovira, Àlex, AutorRuitenberg, Marc J., AutorSamson, Rebecca S., AutorSavini, Giovanni, AutorSeif, Maryam, AutorSeifert, Alan C., AutorSmith, Alex K., AutorSmith, Seth A., AutorSmith, Zachary A., AutorSolana, Elisabeth, AutorSuzuki, Yuichi, AutorTackley, George W, AutorTinnermann, Alexandra, AutorValošek, Jan, AutorVille, Dimitri Van De, AutorYiannakas, Marios C., AutorII, Kenneth A. Weber, AutorWeiskopf, Nikolaus, AutorWise, Richard G., AutorWyss, Patrik O., AutorXu, Junqian, AutorCohen-Adad, Julien, AutorLenglet, Christophe, AutorNestrašil, Igor, Autor mehr..
Affiliations:
1Max Planck Research Group Pain Perception, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2497695              
2Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              

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 Zusammenfassung: Clinical research emphasizes the implementation of rigorous and reproducible study designs that rely on between-group matching or controlling for sources of biological variation such as subject’s sex and age. However, corrections for body size (i.e. height and weight) are mostly lacking in clinical neuroimaging designs. This study investigates the importance of body size parameters in their relationship with spinal cord (SC) and brain magnetic resonance imaging (MRI) metrics. Data were derived from a cosmopolitan population of 267 healthy human adults (age 30.1±6.6 years old, 125 females). We show that body height correlated strongly or moderately with brain gray matter (GM) volume, cortical GM volume, total cerebellar volume, brainstem volume, and cross-sectional area (CSA) of cervical SC white matter (CSA-WM; 0.44≤r≤0.62). In comparison, age correlated weakly with cortical GM volume, precentral GM volume, and cortical thickness (-0.21≥r≥-0.27). Body weight correlated weakly with magnetization transfer ratio in the SC WM, dorsal columns, and lateral corticospinal tracts (-0.20≥r≥-0.23). Body weight further correlated weakly with the mean diffusivity derived from diffusion tensor imaging (DTI) in SC WM (r=-0.20) and dorsal columns (-0.21), but only in males. CSA-WM correlated strongly or moderately with brain volumes (0.39≤r≤0.64), and weakly with precentral gyrus thickness and DTI-based fractional anisotropy in SC dorsal columns and SC lateral corticospinal tracts (-0.22≥r≥-0.25). Linear mixture of sex and age explained 26±10% of data variance in brain volumetry and SC CSA. The amount of explained variance increased at 33±11% when body height was added into the mixture model. Age itself explained only 2±2% of such variance. In conclusion, body size is a significant biological variable. Along with sex and age, body size should therefore be included as a mandatory variable in the design of clinical neuroimaging studies examining SC and brain structure.

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Sprache(n): eng - English
 Datum: 2024-05-01
 Publikationsstatus: Online veröffentlicht
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 Identifikatoren: DOI: 10.1101/2024.04.29.591421
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Titel: bioRxiv
Genre der Quelle: Webseite
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