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  Myelin lipid metabolism can provide energy for starved axons

Asadollahi, E., & Nave, K.-A. (2024). Myelin lipid metabolism can provide energy for starved axons. Nature Neuroscience. doi:10.1038/s41593-024-01750-z.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000F-DDB7-A Version Permalink: https://hdl.handle.net/21.11116/0000-000F-DDB8-9
Genre: Journal Article

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s41593-024-01750-z.pdf (Publisher version), 748KB
 
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 Creators:
Asadollahi, Ebrahim1, Author           
Nave, Klaus-Armin1, Author           
Affiliations:
1Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society, ou_3350301              

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 Abstract: We reveal that lipid turnover in the myelin sheath generates a fatty acid pool in oligodendrocytes that can contribute to the energy balance of white matter tracts. We also demonstrate that when glucose levels are limiting, fatty acid metabolism can support glial cell survival and the basic functional integrity of myelinated axons.

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Language(s): eng - English
 Dates: 2024-09-12
 Publication Status: Published online
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 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41593-024-01750-z
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Title: Nature Neuroscience
  Other : Nat. Neurosci.
Source Genre: Journal
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Publ. Info: New York, NY : Nature America Inc.
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 1097-6256
CoNE: https://pure.mpg.de/cone/journals/resource/954925610931