English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  Variations of cervical vertebrae after expression of a Hox-1.1 transgene in mice.

Kessel, M., Balling, R., & Gruss, P. (1990). Variations of cervical vertebrae after expression of a Hox-1.1 transgene in mice. Cell, 61(2), 301-308. doi:10.1016/0092-8674(90)90810-2.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-0DF8-C Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-E3C2-2
Genre: Journal Article

Files

show Files
hide Files
:
603009.pdf (Publisher version), 7MB
Name:
603009.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Kessel, M.1, Author              
Balling, R.1, Author              
Gruss, P.1, Author              
Affiliations:
1Department of Molecular Cell Biology, MPI for biophysical chemistry, Max Planck Society, ou_578585              

Content

show
hide
Free keywords: -
 Abstract: To understand the function of murine homeobox genes, a genetic analysis is mandatory. We generated gain-of-function mutants by introducing genomic sequences of the Hox-1.1 gene under the control of a chicken beta-actin promoter into mice. Our previous data had shown that these transgenic mice are nonviable after birth and are born with craniofacial abnormalities. In a subsequent detailed analysis of severely affected animals, malformations of the basioccipital bone, the atlas, and the axis were observed. Manifestation of an additional vertebra, a proatlas, occurred at the craniocervical transition. The dominant interference of the Hox-1.1 transgene with developmental programs seems to occur around day 9 of gestation, the time of neural crest migration and somite differentiation. We discuss the resulting phenotype with respect to a developmental control function of Hox-1.1.

Details

show
hide
Language(s): eng - English
 Dates: 1990-04-20
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Cell
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 61 (2) Sequence Number: - Start / End Page: 301 - 308 Identifier: ISSN: 0092-8674