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  Voltage sensitivity of NMDA-receptor mediated postsynaptic currents.

Konnerth, A., Keller, B. U., Ballanyi, K., & Yaari, Y. (1990). Voltage sensitivity of NMDA-receptor mediated postsynaptic currents. Experimental Brain Research, 81(1), 209-212. doi: 10.1007/BF00230117.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-0EA5-B Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-3721-5
Genre: Journal Article

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Konnerth, A.1, Author              
Keller, B. U.1, Author              
Ballanyi, K., Author
Yaari, Y., Author
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1Research Group of Cellular Neurophysiology, MPI for biophysical chemistry, Max Planck Society, ou_578557              

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 Abstract: Patch-clamp techniques were used to record pharmacologically-isolated N-methyl-D-aspartate-mediated excitatory postsynaptic currents (NMDA-EPSCs) from dentate granule cells in thin rat hippocampal slices. Membrane voltage modulated these EPSCs in two ways. Firstly, depolarization from resting potential enhanced EPSC amplitudes, as expected for a voltage-dependent block by Mg2+ of synaptically activated NMDA receptor channels. Secondly, depolarization markedly prolonged the time course of decay of NMDA-EPSCs in normal and low extracellular Mg2+. Both mechanisms were complementary in establishing a strong dependence between membrane potential and the amount of charge, namely Ca2+, transferred through synaptically activated NMDA receptor channels, that presumably underlies induction of long-term potentiation in the hippocampus.

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Language(s): eng - English
 Dates: 1990
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1007/BF00230117
ISI: A1990DM27400023
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Title: Experimental Brain Research
Source Genre: Journal
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Pages: - Volume / Issue: 81 (1) Sequence Number: - Start / End Page: 209 - 212 Identifier: ISSN: 0014-4819