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  Regional differences of fMR signal changes induced by hyperventilation: Comparison between SE-EPI and GE-EPI at 3-T

Naganawa, S., Norris, D. G., Zysset, S., & Mildner, T. (2002). Regional differences of fMR signal changes induced by hyperventilation: Comparison between SE-EPI and GE-EPI at 3-T. Journal of Magnetic Resonance Imaging, 15(1), 23-30. doi:10.1002/jmri.10028.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-D531-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-5BD4-D
Genre: Journal Article

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Naganawa, S., Author
Norris, David G.1, Author              
Zysset, Stefan1, Author              
Mildner, Toralf1, Author              
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1MPI of Cognitive Neuroscience (Leipzig, -2003), The Prior Institutes, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634574              

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 Abstract: PURPOSE: To evaluate whether reproducible signal change of brain tissues by hyperventilation (HV) can be seen on spin-echo (SE)-echo planar imaging (EPI) at 3-T and to examine the sensitivity of SE-EPI for measuring vascular reactivity in regions of the brain, such as the hippocampal formation, that are difficult to visualize with gradient-echo (GE)-EPI due to susceptibility artifacts. MATERIALS AND METHODS: Six healthy human subjects performed a voluntary HV task. The task design was as follows: two minutes normal breathing (rest) followed by two minutes HV, giving a basic four-minute block that was repeated three times for a total scan time of 12 minutes for one run. Each subject performed the run both for SE-EPI and GE-EPI. Statistical analysis was performed to detect the area with significant cerebrovascular reactivity. The percentage signal change was also obtained for each cerebral region. RESULTS: Both GE-EPI and SE-EPI showed globally significant signal decreases in the cerebral cortex. In GE-EPI, the frontal cortex showed a larger signal decrease than the other gray matter tissues (P < 0.05). In SE-EPI, the differences among gray matter tissues except for the hippocampal formation were not significant. The hippocampal formation showed the largest signal change (P < 0.05) in SE-EPI, but no significant signal change was observed in GE-EPI due to the presence of susceptibility artifacts. CONCLUSION: HV using SE-EPI at 3-T provides robust and reproducible signal decreases and may make the evaluation of the vascular reactivity in hippocampal formation feasible.

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Language(s): eng - English
 Dates: 2002
 Publication Status: Published in print
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 Identifiers: eDoc: 239314
DOI: 10.1002/jmri.10028
Other: P6791
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Title: Journal of Magnetic Resonance Imaging
Source Genre: Journal
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Publ. Info: Chicago, IL : Society for Magnetic Resonance Imaging
Pages: - Volume / Issue: 15 (1) Sequence Number: - Start / End Page: 23 - 30 Identifier: ISSN: 1053-1807
CoNE: https://pure.mpg.de/cone/journals/resource/954925594512