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  Neuroanatomical prerequisites for language functions in the maturing brain

Brauer, J., Anwander, A., & Friederici, A. D. (2011). Neuroanatomical prerequisites for language functions in the maturing brain. Cerebral Cortex, 21(2), 459-466. doi:10.1093/cercor/bhq108.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0011-28B4-D Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-FFA0-B
Genre: Journal Article

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 Creators:
Brauer, Jens1, Author              
Anwander, Alfred2, Author              
Friederici, Angela D.1, Author              
Affiliations:
1Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
2Methods and Development Unit Cortical Networks and Cognitive Functions, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634557              

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Free keywords: Development; DTI; Fiber tractography; fMRI; Language
 Abstract: The 2 major language-relevant cortical regions in the human brain, Broca's area and Wernicke's area, are connected via the fibers of the arcuate fasciculus/superior longitudinal fasciculus (AF/SLF). Here, we compared this pathway in adults and children and its relation to language processing during development. Comparison of fiber properties demonstrated lower anisotropy in children's AF/SLF, arguing for an immature status of this particular pathway with conceivably a lower degree of myelination. Combined diffusion tensor imaging (DTI) data and functional magnetic resonance imaging (fMRI) data indicated that in adults the termination of the AF/SLF fiber projection is compatible with functional activation in Broca's area, that is pars opercularis. In children, activation in Broca's area extended from the pars opercularis into the pars triangularis revealing an alternative connection to the temporal lobe (Wernicke's area) via the ventrally projecting extreme capsule fiber system. fMRI and DTI data converge to indicate that adults make use of a more confined language network than children based on ongoing maturation of the structural network. Our data suggest relations between language development and brain maturation and, moreover, indicate the brain's plasticity to adjust its function to available structural prerequisites.

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Language(s): eng - English
 Dates: 2011-02
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 538214
DOI: 10.1093/cercor/bhq108
Other: P10234
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Title: Cerebral Cortex
Source Genre: Journal
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Publ. Info: New York, NY : Oxford University Press
Pages: - Volume / Issue: 21 (2) Sequence Number: - Start / End Page: 459 - 466 Identifier: ISSN: 1047-3211
CoNE: /journals/resource/954925592440