The Core Structures of Roseophilin and the Prodigiosin Alkaloids Define a New 
Class of Protein Tyrosine Phosphatase Inhibitors

Fürstner, Alois; Reinecke, Kerstin; Prinz, Heino; Waldmann, Herbert

doi:10.1002/cbic.200400135

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The Core Structures of Roseophilin and the Prodigiosin Alkaloids Define a New Class of Protein Tyrosine Phosphatase Inhibitors

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Fürstner, Alois
Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Citation

Fürstner, A., Reinecke, K., Prinz, H., & Waldmann, H. (2004). The Core Structures of Roseophilin and the Prodigiosin Alkaloids Define a New Class of Protein Tyrosine Phosphatase Inhibitors. ChemBioChem: A European Journal of Chemical Biology, 5(11), 1575-1579. doi:10.1002/cbic.200400135.

Cite as: https://hdl.handle.net/11858/00-001M-0000-000F-975B-1

Abstract

A common core. Protein phosphatases, such as the dual-specificity phosphatase VHR and the tyrosine phosphatase PTP1B, are key regulators of innumerable cellular processes, and new classes of phosphatase inhibitors are in demand. The azafulvene-containing core structures of the roseophilin and prodigiosin alkaloids define such a new class.