Immunological outcomes of new tuberculosis vaccine trials: WHO panel 
recommendations

Hanekom, Willem A.; Dockrell, Hazel M.; Ottenhoff, Tom H. M.; Doherty, T. Mark; Fletcher, Helen; McShane, Helen; Weichold, Frank F.; Hoft, Dan F.; Parida, Shreemanta K.; Fruth, Uli J.

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Immunological outcomes of new tuberculosis vaccine trials: WHO panel recommendations

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Parida, Shreemanta K.
Department of Immunology, Max Planck Institute for Infection Biology, Max Planck Society;

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PLoS_Med_2008_5_e145_1033.pdf
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Zitation

Hanekom, W. A., Dockrell, H. M., Ottenhoff, T. H. M., Doherty, T. M., Fletcher, H., McShane, H., et al. (2008). Immunological outcomes of new tuberculosis vaccine trials: WHO panel recommendations. PLoS Medicine, 5(7): 145, pp. 1033-1036.

Zitierlink: https://hdl.handle.net/11858/00-001M-0000-000E-C1AE-7

Zusammenfassung

Summary Points * Many new and diverse tuberculosis vaccines are currently under development. * The ability to compare clinical immunogenicity between different candidates would be an important asset. * The World Health Organization (WHO) Initiative for Vaccine Research sponsored three meetings of experts to discuss assay harmonization for new tuberculosis vaccine trials. * We describe advantages and disadvantages of multiple T cell assay approaches and make specific recommendations for phase I/IIa trials. These include introducing a single and simple harmonised assay for all trials.