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Journal Article

Dopaminergic modulation of semantic network activation

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Kischka, U., Kammer, T., Weisbrod M, Maier S, Thimm, M., & Spitzer, M. (1996). Dopaminergic modulation of semantic network activation. Neuropsychologia, 34(11), 1107-1113. doi:10.1016/0028-3932(96)00024-3.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0013-EBE8-7
In order to examine the effect of dopamine on semantic processing, we performed a double-blind, placebo-controlled study. Healthy volunteers (n = 31) were tested in a lexical decision paradigm after ingestion of either L-dopa 100 mg with benserazide 25 mg or placebo. While direct semantic priming was influenced only marginally by L-dopa, the indirect priming effect was reduced significantly. These data support the hypothesis that dopamine increases the signal-to-noise ratio in semantic networks by reducing the spread of semantic processing, thereby leading to a focussing of activation. Copyright (C) 1996 Elsevier Science Ltd.