Grey matter changes in motor conversion disorder

Aybek, Selma; Nicholson, Timothy R. J.; Draganski, Bogdan; Daly, Eileen; Murphy, Declan G.; David, Anthony S.; Kanaan, Richard A.

doi:10.1136/jnnp-2012-304158

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Grey matter changes in motor conversion disorder

MPS-Authors

/persons/resource/persons19617

Draganski, Bogdan
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Département des Neurosciences Cliniques, Laboratoire de Recherche en Neuroimagerie (LREN), Centre hospitalier universitaire vaudois, Lausanne, Switzerland;
Berlin School of Mind and Brain, Humboldt University Berlin, Germany;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Aybek, S., Nicholson, T. R. J., Draganski, B., Daly, E., Murphy, D. G., David, A. S., et al. (2014). Grey matter changes in motor conversion disorder. Journal of Neurology, Neurosurgery & Psychiatry, 85(2), 236-238. doi:10.1136/jnnp-2012-304158.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0024-518B-A

Abstract

Objective: To detect anatomical differences in areas related to motor processing between patients with motor conversion disorder (CD) and controls.

Methods: T1-weighted 3T brain MRI data of 15 patients suffering from motor CD (nine with hemiparesis and six with paraparesis) and 25 age- and gender-matched healthy volunteers were compared using voxel-based morphometry (VBM) and voxel-based cortical thickness (VBCT) analysis.

Results: We report significant cortical thickness (VBCT) increases in the bilateral premotor cortex of hemiparetic patients relative to controls and a trend towards increased grey matter volume (VBM) in the same region. Regression analyses showed a non-significant positive correlation between cortical thickness changes and symptom severity as well as illness duration in CD patients.

Conclusions: Cortical thickness increases in premotor cortical areas of patients with hemiparetic CD provide evidence for altered brain structure in a condition with presumed normal brain anatomy. These may either represent premorbid vulnerability or a plasticity phenomenon related to the disease with the trends towards correlations with clinical variables supporting the latter.