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Studies on conditional gene expression in the brain

MPS-Authors
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Jerecic,  Jasna
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Single,  Frank Nicolai
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Krüth,  Ulrich
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Krestel,  Heinz Eric
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Higuchi,  Miyoko
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Sprengel,  Rolf
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Seeburg,  Peter H.
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Jerecic, J., Single, F. N., Krüth, U., Krestel, H. E., Kolhekar, R., Storck, T., et al. (1999). Studies on conditional gene expression in the brain. Annals of the New York Academy of Sciences, 868, 27-37. doi:10.1111/j.1749-6632.1999.tb11271.x.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0024-6071-9
Abstract
This manuscript summarizes our recent attempts to regulate in vitro and in vivo the expression of genes encoding components and regulators of the postsynaptic machinery along with marker genes such as lacZ and GFP. In particular, we studied tTA-dependent regulation and utilized Cre in combination with reversible silencing by intron engineering of dominant negative alleles. We further present a "knockin" approach for on-site artificial regulation of chromosomal genes.