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Journal Article

Redesigning antidepressant drug discovery. [Guest Editorial]

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Holsboer,  Florian
Max Planck Institute of Psychiatry, Max Planck Society;

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Citation

Holsboer, F. (2014). Redesigning antidepressant drug discovery. [Guest Editorial]. Dialogues in clinical neuroscience, 16(1), 5-7.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0027-7780-6
Abstract
Antidepressant drug discovery and development have been put on hold by many pharmaceutical companies. The main reason for this is the negative efficacy studies with novel specific drugs. Here I argue that the main obstacles are the absence of gene tests and biomarkers as an integral part of a diagnostic process. Further, too much emphasis has been put on validating drug candidates in animal models of psychiatric disorders. A more rapid transfer of drug candidates into human research is necessary to overcome current obstacles that prevent the discovery of next-generation antidepressants.