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Journal Article

Direct action of endocrine disrupting chemicals on human sperm

MPS-Authors
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Schiffer,  Christian
Department of Molecular Sensory Systems, Center of Advanced European Studies and Research (caesar), Max Planck Society;

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Müller,  Astrid
Department of Molecular Sensory Systems, Center of Advanced European Studies and Research (caesar), Max Planck Society;

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Alvarez,  Luis
Department of Molecular Sensory Systems, Center of Advanced European Studies and Research (caesar), Max Planck Society;

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Brenker,  Christoph
Department of Molecular Sensory Systems, Center of Advanced European Studies and Research (caesar), Max Planck Society;

Wäschle,  Benjamin
Department of Molecular Sensory Systems, Center of Advanced European Studies and Research (caesar), Max Planck Society;

/persons/resource/persons182743

Kaupp,  Ulrich Benjamin
Department of Molecular Sensory Systems, Center of Advanced European Studies and Research (caesar), Max Planck Society;

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Balbach,  Melanie
Department of Molecular Sensory Systems, Center of Advanced European Studies and Research (caesar), Max Planck Society;

/persons/resource/persons182737

Wachten,  Dagmar
Max Planck Research Group Molecular Physiology, Center of Advanced European Studies and Research (caesar), Max Planck Society;

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Strünker,  Timo
Department of Molecular Sensory Systems, Center of Advanced European Studies and Research (caesar), Max Planck Society;

External Resource

https://www.embopress.org/doi/full/10.15252/embr.201438869
(Abstract)

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Citation

Schiffer, C., Müller, A., Egeberg, D. L., Alvarez, L., Brenker, C., Rehfeld, A., et al. (2014). Direct action of endocrine disrupting chemicals on human sperm. EMBO Reports, 15(7), 758-765. doi:10.15252/embr.201438869.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0028-6195-9
Abstract
Synthetic endocrine disrupting chemicals (EDCs), omnipresent in
food, household, and personal care products, have been implicated
in adverse trends in human reproduction, including infertility and
increasing demand for assisted reproduction. Here, we study the
action of 96 ubiquitous EDCs on human sperm. We show that
structurally diverse EDCs activate the sperm-specific CatSper
channel and, thereby, evoke an intracellular Ca2+ increase, a motility response, and acrosomal exocytosis. Moreover, EDCs desensitize sperm for physiological CatSper ligands and cooperate in
low-dose mixtures to elevate Ca2+ levels in sperm. We conclude
that EDCs interfere with various sperm functions and, thereby,
might impair human fertilization.