Distinguishing N-acetylneuraminic acid linkage isomers on glycopeptides by ion 
mobility-mass spectrometry

Hinneburg, Hannes; Hofmann, Johanna; Struwe, W. B.; Thader, A.; Altmann, F.; Varón Silva, Daniel; Seeberger, Peter H.; Pagel, Kevin; Kolarich, Daniel

doi:10.1039/C6CC01114D

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Distinguishing N-acetylneuraminic acid linkage isomers on glycopeptides by ion mobility-mass spectrometry

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Hinneburg, Hannes
Daniel Kolarich, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Hofmann, Johanna
Department of Biology, Chemistry, Pharmacy, Freie Universität Berlin;
Molecular Physics, Fritz Haber Institute, Max Planck Society;

/persons/resource/persons127124

Varón Silva, Daniel
Daniel Varón Silva, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Seeberger, Peter H.
Department of Biology, Chemistry, Pharmacy, Freie Universität Berlin;
Peter H. Seeberger, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

/persons/resource/persons32738

Pagel, Kevin
Department of Biology, Chemistry, Pharmacy, Freie Universität Berlin;
Molecular Physics, Fritz Haber Institute, Max Planck Society;

/persons/resource/persons121498

Kolarich, Daniel
Daniel Kolarich, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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引用

Hinneburg, H., Hofmann, J., Struwe, W. B., Thader, A., Altmann, F., Varón Silva, D., Seeberger, P. H., Pagel, K., & Kolarich, D. (2016). Distinguishing N-acetylneuraminic acid linkage isomers on glycopeptides by ion mobility-mass spectrometry. Chemical Communications, 52(23), 4381-4384. doi:10.1039/C6CC01114D.

引用: https://hdl.handle.net/11858/00-001M-0000-002A-1E81-8

要旨

Differentiating the structure of isobaric glycopeptides represents a major challenge for mass spectrometry-based characterisation techniques. Here we show that the regiochemistry of the most common N-acetylneuraminic acid linkages of N-glycans can be identified in a site-specific manner from individual glycopeptides using ion mobility-mass spectrometry analysis of diagnostic fragment ions.