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  Distinguishing N-acetylneuraminic acid linkage isomers on glycopeptides by ion mobility-mass spectrometry

Hinneburg, H., Hofmann, J., Struwe, W. B., Thader, A., Altmann, F., Varón Silva, D., et al. (2016). Distinguishing N-acetylneuraminic acid linkage isomers on glycopeptides by ion mobility-mass spectrometry. Chemical Communications, 52(23), 4381-4384. doi:10.1039/C6CC01114D.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-1E81-8 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-A454-E
Genre: Journal Article

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c6cc01114d.pdf (Publisher version), 3MB
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2016
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 Creators:
Hinneburg, Hannes1, Author              
Hofmann, Johanna2, 3, Author              
Struwe, W. B.4, Author
Thader, A.5, Author
Altmann, F.5, Author
Varón Silva, Daniel6, Author              
Seeberger, Peter H.2, 7, Author              
Pagel, Kevin2, 3, Author              
Kolarich, Daniel1, Author              
Affiliations:
1Daniel Kolarich, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863301              
2Department of Biology, Chemistry, Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany , ou_persistent22              
3Molecular Physics, Fritz Haber Institute, Max Planck Society, ou_634545              
4Department of Chemistry, Physical and Theoretical Chemistry Laboratory, University of Oxford, OX1 3QZ, Oxford, UK, ou_persistent22              
5Department of Chemistry, University of Natural Resources and Applied Life Sciences, Vienna, Austria , ou_persistent22              
6Daniel Varón Silva, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863302              
7Peter H. Seeberger, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2040285              

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 Abstract: Differentiating the structure of isobaric glycopeptides represents a major challenge for mass spectrometry-based characterisation techniques. Here we show that the regiochemistry of the most common N-acetylneuraminic acid linkages of N-glycans can be identified in a site-specific manner from individual glycopeptides using ion mobility-mass spectrometry analysis of diagnostic fragment ions.

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 Dates: 2016-02-032016-02-242016-02-242016-03-21
 Publication Status: Published in print
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1039/C6CC01114D
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Title: Chemical Communications
  Other : Chem. Commun.
Source Genre: Journal
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Publ. Info: Cambridge, UK : Royal Society of Chemistry
Pages: 4 Volume / Issue: 52 (23) Sequence Number: - Start / End Page: 4381 - 4384 Identifier: ISSN: 1359-7345
CoNE: /journals/resource/954928495413