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Map the light-driven fMRI signal in combination with in vivo recording

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/persons/resource/persons192832

Wang,  M
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons192829

He,  Y
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons192855

Tang,  Y
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons83793

Balla,  DZ
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons133486

Yu,  X
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Wang, M., He, Y., Tang, Y., Balla, D., Qian, C., & Yu, X. (2015). Map the light-driven fMRI signal in combination with in vivo recording. Poster presented at 23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2015), Toronto, Canada.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002A-45ED-0
Abstract
It remains ambiguous how the direct fiber optic insertion affects the local fMRI signal by optical stimulation. The fiber optic was inserted to target the deep layer cortex expressing Channelrhodopsin 2(ChR2). Robust fMRI signal was detected in the cortical regions close to the fiber tip with varied light pulse parameters on frequency, pulse duration and power level. The light evoked local field potential was also recorded by electrodes inserted into the cortex expressing ChR2. This work provides us a robust light-driven fMRI platform in combination with in vivo recording, which will facilitate the study to decipher cellular contribution to fMRI signal from the local neurovascular network.