Multitasking of Interferon Regulatory Factor-4 in Early B Cells

Nielsen, Peter; Grosschedl, Rudolf

doi:10.1016/j.immuni.2008.02.007

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Multitasking of Interferon Regulatory Factor-4 in Early B Cells

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Nielsen, Peter
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Grosschedl, Rudolf
Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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https://www.sciencedirect.com/science/article/pii/S1074761308000794?via%3Dihub
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Citation

Nielsen, P., & Grosschedl, R. (2008). Multitasking of Interferon Regulatory Factor-4 in Early B Cells. Immunity, 28, 295-297. doi:10.1016/j.immuni.2008.02.007.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002B-9009-6

Abstract

Immunoglobulin heavy- and light-chain genes are rearranged in a temporally ordered manner. In this issue, Johnson et al. (2008) show that interferon regulatory factor-4 regulates light-chain gene rearrangement by activating enhancers and attenuating interleukin-7 signaling.