Blurring cis and trans in Gene Regulation

Savarese, Fabio; Grosschedl, Rudolf

doi:10.1016/j.cell.2006.07.008

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Blurring cis and trans in Gene Regulation

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Savarese, Fabio
Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Grosschedl, Rudolf
Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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https://www.sciencedirect.com/science/article/pii/S0092867406009019?via%3Dihub
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Citation

Savarese, F., & Grosschedl, R. (2006). Blurring cis and trans in Gene Regulation. Cell, 126, 248-250. doi:10.1016/j.cell.2006.07.008.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002B-9240-5

Abstract

In this issue of Cell, Axel and colleagues (Lomvardas et al., 2006) report that a single enhancer of an odorant receptor (OR) gene cluster interacts with multiple OR gene promoters on different chromosomes. This study suggests a mechanism that allows olfactory sensory neurons to choose randomly and express only one out of more than 1000 OR genes.