Role of transcription factors in commitment and differentiation of early B 
lymphoid cells

Roessler, Stephanie; Grosschedl, Rudolf

doi:10.1016/j.smim.2005.12.001

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Role of transcription factors in commitment and differentiation of early B lymphoid cells

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Roessler, Stephanie
Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Grosschedl, Rudolf
Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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https://www.sciencedirect.com/science/article/pii/S1044532305000965?via%3Dihub
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Citation

Roessler, S., & Grosschedl, R. (2006). Role of transcription factors in commitment and differentiation of early B lymphoid cells. Seminars in Immunology, 18, 12-19. doi:10.1016/j.smim.2005.12.001.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002B-92AA-C

Abstract

B lymphopoiesis is a differentiation process in which hematopoietic stem cells are converted into antibody-producing plasma cells. B cell differentiation involves multiple steps, including cell specification, commitment to the B cell lineage, immunoglobulin rearrangements, maturation of B cells and terminal differentiation into plasma cells. Each of these steps is controlled by signaling pathways and transcription factors that act in synergy, feedback-loops or cross-antagonism to generate complex regulatory networks that allow for plasticity and stability of B cell differentiation.