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Thymopoiesis requires Pax9 function in thymic epithelial cells

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Hetzer-Egger,  Claudia
Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Schorpp,  Michael
Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Haas-Assenbaum,  Annette
Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Boehm,  Thomas
Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Citation

Hetzer-Egger, C., Schorpp, M., Haas-Assenbaum, A., Balling, R., Peters, H., & Boehm, T. (2002). Thymopoiesis requires Pax9 function in thymic epithelial cells. European Journal of Immunology, 32(4), 1175-1181. doi:10.1002/1521-4141(200204)32:4<1175:AID-IMMU1175>3.0.CO;2-U.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002B-9654-8
Abstract
The epithelial thymic anlage develops from the third pharyngeal pouch. Pax9 is expressed in the entire pharyngeal endoderm, and its function is required for normal development of organs derived from pharyngeal pouches. Here, we show that in Pax9 null mice, the thymic anlage develops as an ectopic polyp-like structure in the larynx. It expresses Whn/Foxn1, a marker of thymic epithelium, but fails to perform the normal caudo-ventral movement to the upper mediastinum. The thymic rudiment contains mesenchymal cells, blood vessels and is colonized by T cell progenitors. However, from embryonic day 14.5 onwards, the size of the Pax9 mutant thymus is severely reduced. Whereas expression of TCRβ chain genes is readily detectable in the mutant thymus, no expression of the TCRγ chain was detectable. Our results identify a new genetically defined control point of thymopoiesis.