Antibodies for prevention and treatment of diseases caused by Clostridium 
difficile

Seeberger, Peter H.; Martin, Christopher E.; Bröcker, Felix; Chakkumkal, Anish

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特許

Antibodies for prevention and treatment of diseases caused by Clostridium difficile

MPS-Authors

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Seeberger, Peter H.
Peter H. Seeberger - Vaccine Development, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Martin, Christopher E.
Peter H. Seeberger - Vaccine Development, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Bröcker, Felix
Chakkumal Anish, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Chakkumkal, Anish
Chakkumal Anish, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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2364357.pdf
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引用

Seeberger, P. H., Martin, C. E., Bröcker, F., & Chakkumkal, A.(2016). Antibodies for prevention and treatment of diseases caused by Clostridium difficile.

引用: https://hdl.handle.net/11858/00-001M-0000-002C-0391-E

要旨

The present invention relates to an antibody having specificity for an immunogenic determinant consisting of the pentasaccharide repeating unit of the Clostridium difficile glycopolymer PS-I: α-L-Rhap-(1→3)-β-D-Glcp-(1→4)-[α-L-Rhap-(1→3)]-α-D-Glcp-(1→2)-α-D-Glcp or a fragment thereof. Said antibody is able to prevent and treat diseases caused by C. difficile. The present invention further pertains to a method of treating or preventing a disease caused by the pathogen Clostridium difficile, which comprises administering to a subject said antibody or a vaccine composition comprising said antibody.