English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
  Local TagsRelease HistoryDetailsSummary

Released
Journal Article

How to control cyclic nucleotide signaling by light

MPS-Authors
/persons/resource/persons182740

Jansen,  Vera
Department of Molecular Sensory Systems, Center of Advanced European Studies and Research (caesar), Max Planck Society;

/persons/resource/persons182741

Jikeli,  Jan
Department of Molecular Sensory Systems, Center of Advanced European Studies and Research (caesar), Max Planck Society;

/persons/resource/persons182737

Wachten,  Dagmar
Max Planck Research Group Molecular Physiology, Center of Advanced European Studies and Research (caesar), Max Planck Society;

External Resource

http://www.sciencedirect.com/science/article/pii/S0958166916302968
(Publisher version)

Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Jansen, V., Jikeli, J., & Wachten, D. (2017). How to control cyclic nucleotide signaling by light. Current Opinion in Biotechnology, 48, 15-20. doi:10.1016/j.copbio.2017.02.014.


Cite as: https://hdl.handle.net/11858/00-001M-0000-002C-AF54-7
Abstract
Highlights
- Optogenetics controls cyclic nucleotide signaling with spatio-temporal resolution.
- Genetic-engineering creates new tools by combining photosensory and effector domains.
- Optogenetic control of cyclic nucleotide signaling controls physiological functions.
Abstract
Optogenetics allows to non-invasively manipulate cellular functions with spatio-temporal precision by combining genetic engineering with the control of protein function by light. Since the discovery of channelrhodopsin has pioneered the field, the optogenetic toolkit has been ever expanding and allows now not only to control neuronal activity by light, but rather a multitude of other cellular functions. One important application that has been established in recent years is the light-dependent control of second messenger signaling. The optogenetic toolkit now allows to control cyclic nucleotide-dependent signaling by light in vitro and in vivo.