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Journal Article

Hyperpolarization of amino acid derivatives in water for biological applications.

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Glöggler,  S.
Research Group of NMR Signal Enhancement, MPI for Biophysical Chemistry, Max Planck Society;

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2495902.pdf
(Publisher version), 443KB

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Citation

Glöggler, S., Wagner, S., & Bouchard, L. S. (2015). Hyperpolarization of amino acid derivatives in water for biological applications. The Royal Society of Chemistry, 6, 4261-4266. doi:10.1039/C5SC00503E.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002E-2398-A
Abstract
We report on the successful synthesis and hyperpolarization of N-unprotected α-amino acid ethyl propionate esters and extensively, on an alanine derivative hyperpolarized by PHIP (4.4 ± 1.0% 13C-polarization), meeting required levels for in vivo detection. Using water as solvent increases biocompatibility and the absence of N-protection is expected to maintain biological activity.