Transmitter regulation of voltage-dependent K+ channels expressed in Xenopus 
oocytes

Kavanaugh, M. P.; Christie, M. J.; Osborne, P. B.; Busch, A. E.; Shen, K. Z.; Wu, Y. N.; Seeburg, Peter H.; Adelman, John P.; North, R. A.

doi:10.1042/bj2770899

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Transmitter regulation of voltage-dependent K+ channels expressed in Xenopus oocytes

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Seeburg, Peter H.
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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http://www.biochemj.org/content/277/3/899.full-text.pdf
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1151331/pdf/biochemj00154-0305.pdf
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https://doi.org/10.1042/bj2770899
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Citation

Kavanaugh, M. P., Christie, M. J., Osborne, P. B., Busch, A. E., Shen, K. Z., Wu, Y. N., et al. (1991). Transmitter regulation of voltage-dependent K+ channels expressed in Xenopus oocytes. Biochemical Journal, 277(3), 899-902. doi:10.1042/bj2770899.

Cite as: https://hdl.handle.net/21.11116/0000-0000-7327-3

Abstract

Voltage-dependent K+ channels (RBK1, RBK2 and RGK5) were co-expressed in Xenopus oocytes with 5-hydroxytryptamine (5-HT2) receptors. K+ currents measured 2-4 days later were inhibited by 5-HT (100 nM-10 microM, 20-30 s application) by up to 90%. The effect of 5-HT was mimicked by intracellular injection of Ins(1,4,5)P3. Increasing the Ca2+ concentration at the inner surface of excised membrane patches did not decrease the K+ current.