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Journal Article

Transmitter regulation of voltage-dependent K+ channels expressed in Xenopus oocytes

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Seeburg,  Peter H.
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Kavanaugh, M. P., Christie, M. J., Osborne, P. B., Busch, A. E., Shen, K. Z., Wu, Y. N., et al. (1991). Transmitter regulation of voltage-dependent K+ channels expressed in Xenopus oocytes. Biochemical Journal, 277(3), 899-902. doi:10.1042/bj2770899.


Cite as: http://hdl.handle.net/21.11116/0000-0000-7327-3
Abstract
Voltage-dependent K+ channels (RBK1, RBK2 and RGK5) were co-expressed in Xenopus oocytes with 5-hydroxytryptamine (5-HT2) receptors. K+ currents measured 2-4 days later were inhibited by 5-HT (100 nM-10 microM, 20-30 s application) by up to 90%. The effect of 5-HT was mimicked by intracellular injection of Ins(1,4,5)P3. Increasing the Ca2+ concentration at the inner surface of excised membrane patches did not decrease the K+ current.