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Meeting Abstract

Characterization of the macromolecular baseline with a metabolite-cycled double-inversion recovery sequence in the human brain at 9.4T

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Giapitzakis,  IA
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons84402

Henning,  A
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Giapitzakis, I., Kreis, R., & Henning, A. (2016). Characterization of the macromolecular baseline with a metabolite-cycled double-inversion recovery sequence in the human brain at 9.4T. In 24th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2016).


Cite as: https://hdl.handle.net/21.11116/0000-0000-7CE0-8
Abstract
Macromolecular resonances (MM) overlap with metabolites resulting in inaccurate quantification of the metabolites due to baseline distortion. This effect becomes even more severe in case of short echo times (TE). The purpose of this study was the development of an adiabatic pulse for double inversion recovery and investigation of impact to include MM into quantification of 9.4T MRS data of human brain. This is the first study where MC-STEAM is combined with a double inversion technique. The results showed the advantages of UHF and MC as well as the necessity of the inclusion of MM baseline in the basis set.