Gonadal development and gametogenesis in the hypogonadal mouse are restored by 
gene transfer

Mason, Anthony J.; Pitts, A. L.; Nikolics, Károly; Szonyi, E.; Szonyi, J. N.; Seeburg, Peter H.; Stewart, T. A.

doi:10.1111/j.1749-6632.1987.tb24995.x

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Gonadal development and gametogenesis in the hypogonadal mouse are restored by gene transfer

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Seeburg, Peter H.
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Mason, A. J., Pitts, A. L., Nikolics, K., Szonyi, E., Szonyi, J. N., Seeburg, P. H., et al. (1987). Gonadal development and gametogenesis in the hypogonadal mouse are restored by gene transfer. Annals of the New York Academy of Sciences, 513, 16-26. doi:10.1111/j.1749-6632.1987.tb24995.x.

Cite as: https://hdl.handle.net/21.11116/0000-0000-C8DC-7

Abstract

These results describe controlled regulation of a mammalian neural gene in transgenic mice. Analysis of truncated GnRH-GAP genes in transgenic mice will enable us to define the DNA sequences responsible for this control. Furthermore, by separate mutation of the GnRH and GAP coding sequences we will be able to determine the relative importance of these two peptides in the development and maintenance of reproductive function.