Pseudomonas aeruginosa secretes and correctly processes human growth hormone

Gray, Gregory L.; McKeown, Kathleen A.; Jones, Andrew J. S.; Seeburg, Peter H.; Heyneker, Herbert L.

doi:10.1038/nbt0284-161

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Pseudomonas aeruginosa secretes and correctly processes human growth hormone

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Seeburg, Peter H.
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Gray, G. L., McKeown, K. A., Jones, A. J. S., Seeburg, P. H., & Heyneker, H. L. (1984). Pseudomonas aeruginosa secretes and correctly processes human growth hormone. Nature Biotechnology, 2, 161-165. doi:10.1038/nbt0284-161.

Cite as: https://hdl.handle.net/21.11116/0000-0000-D579-8

Abstract

Pseudomonas aeruginosa transformed with a plasmid containing a gene encoding the mature form of human growth hormone (hGH) preceded by an ATG codon to initiate translation expresses methionyl-hGH its cytoplasm. hGH produced in P. aeruginosa cells transformed with a plasmid containing a gene for the natural hGH precursor is transported across the inner membrane and has the NH2-terminal amino acid sequence of authentic mature hGH.