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Journal Article

Combined RNAi and localization for functionally dissecting long non-coding RNAs

MPS-Authors
/persons/resource/persons219061

Chakraborty,  Debojyoti
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219291

Kappei,  Dennis
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219731

Theis,  Mirko
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219490

Nitzsche,  Anja
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219114

Ding,  Li
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219522

Paszkowski-Rogacz,  Maciej
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219716

Surendranath,  Vineeth
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219004

Berger,  Nicolas
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

Saar,  Kathrin
Max Planck Society;

/persons/resource/persons219042

Buchholz,  Frank
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Chakraborty, D., Kappei, D., Theis, M., Nitzsche, A., Ding, L., Paszkowski-Rogacz, M., et al. (2012). Combined RNAi and localization for functionally dissecting long non-coding RNAs. Nature Methods, 9(4), 360-362.


Cite as: https://hdl.handle.net/21.11116/0000-0001-07F7-1
Abstract
Whereas methods to comprehensively study cellular roles of protein-coding genes are available, techniques to systematically investigate long noncoding RNAs (lncRNAs), which have been implicated in diverse biological pathways, are limited. Here we report combined knockdown and localization analysis of noncoding RNAs (c-KLAN) that merges functional characterization and localization approaches to study lncRNAs. Using this technique we identified transcripts that regulate mouse embryonic stem cell identity.