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Journal Article

Caveolin-1 is essential for liver regeneration

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Ferguson,  Charles
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219360

Kurzchalia,  Teymuras
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Fernandez, M. A., Albor, C., Ingelmo-Torres, M., Nixon, S. J., Ferguson, C., Kurzchalia, T., et al. (2006). Caveolin-1 is essential for liver regeneration. Science, 313(5793), 1628-1632.


Cite as: https://hdl.handle.net/21.11116/0000-0001-1017-3
Abstract
Liver regeneration is an orchestrated cellular response that coordinates cell activation, lipid metabolism, and cell division. We found that caveolin-1 gene-disrupted mice (cav1-/- mice) exhibited impaired liver regeneration and low survival after a partial hepatectomy. Hepatocytes showed dramatically reduced lipid droplet accumulation and did not advance through the cell division cycle. Treatment of cav1-/- mice with glucose (which is a predominant energy substrate when compared to lipids) drastically increased survival and reestablished progression of the cell cycle. Thus, caveolin-1 plays a crucial role in the mechanisms that coordinate lipid metabolism with the proliferative response occurring in the liver after cellular injury.