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Book Chapter

Regulation of growth hormone messenger RNA


Seeburg,  Peter H.
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Martial, J. A., Seeburg, P. H., Matulich, D. T., Goodman, H. M., & Baxter, J. D. (1979). Regulation of growth hormone messenger RNA. In J. D. Baxter, & G. G. Rousseau (Eds.), Monographs on endocrinology (Chapter 15, pp. 279-289). Heidelberg / Berlin / New York: Springer.

Cite as: https://hdl.handle.net/21.11116/0000-0001-29EB-9
In cultured rat pituitary cells, glucocorticoids regulate growth hormone production by modulating the number of growth hormone messenger RNA molecules. The effect is quite specific, since only a few other mRNAs are affected by the hormones. This response is demonstrated by assays involving cell-free mRNA translation and cDNA-RNA hybridization. Furthermore, the inducibility by the glucocorticoids is regulated by at least one other class of hormones, thyroid hormone. Thus, this system serves as a model for studying not only the glucocorticoid regulation of specific mRNA, but also the control of this regulation by other factors in the target tissue.