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Meeting Abstract

Multimodal PET-MRS Investigation of Glutamate-Dependent Neuroreceptor Plasticity in the Healthy Human Brain

MPS-Authors
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Henning,  Anke
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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http://www.ismrm.org/14/program_files/Session37.htm
(Abstract)

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Citation

Scheidegger, M., Fuchs, A., Ametamey, S., Kuhn, F., Johayem, A., Buck, A., et al. (2014). Multimodal PET-MRS Investigation of Glutamate-Dependent Neuroreceptor Plasticity in the Healthy Human Brain. In Joint Annual Meeting ISMRM-ESMRMB 2014.


Cite as: https://hdl.handle.net/21.11116/0000-0001-33F5-1
Abstract
In this multimodal, double-blind, randomized, placebo-controlled PET-MRS study in 20 healthy subjects, we report a pharmacological modulation of glutamate-dependent neuroreceptor plasticity in the pregenual anterior cingulate cortex following the administration of the NMDA-receptor antagonist ketamine. In order to investigate the functional interplay between the major excitatory neurotransmitter glutamate (Glu) and the density of the metabotropic glutamate receptor subtype 5 (mGluR5) we combined proton magnetic resonance spectroscopy (1H-MRS) with positron emission tomography (11C-ABP688-PET). Our findings complement previous reports of increased glutamate release during ketamine challenge by providing additional in vivo molecular imaging evidence for ketamine-induced neurotransmitter-receptor coupling.