English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Meeting Abstract

Multimodal PET-MRS Investigation of Glutamate-Dependent Neuroreceptor Plasticity in the Healthy Human Brain

MPS-Authors
/persons/resource/persons84402

Henning,  Anke
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

Fulltext (public)
There are no public fulltexts available
Supplementary Material (public)
There is no public supplementary material available
Citation

Scheidegger, M., Fuchs, A., Ametamey, S., Kuhn, F., Johayem, A., Buck, A., et al. (2014). Multimodal PET-MRS Investigation of Glutamate-Dependent Neuroreceptor Plasticity in the Healthy Human Brain. In Joint Annual Meeting ISMRM-ESMRMB 2014.


Cite as: http://hdl.handle.net/21.11116/0000-0001-33F5-1
Abstract
In this multimodal, double-blind, randomized, placebo-controlled PET-MRS study in 20 healthy subjects, we report a pharmacological modulation of glutamate-dependent neuroreceptor plasticity in the pregenual anterior cingulate cortex following the administration of the NMDA-receptor antagonist ketamine. In order to investigate the functional interplay between the major excitatory neurotransmitter glutamate (Glu) and the density of the metabotropic glutamate receptor subtype 5 (mGluR5) we combined proton magnetic resonance spectroscopy (1H-MRS) with positron emission tomography (11C-ABP688-PET). Our findings complement previous reports of increased glutamate release during ketamine challenge by providing additional in vivo molecular imaging evidence for ketamine-induced neurotransmitter-receptor coupling.