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Multiple Interleaved Mode Saturation (MIMOSA) for B1+ inhomogeneity mitigation in chemical exchange saturation transfer

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Zaiss,  M
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Liebert, A., Zaiss, M., Gumbrecht, R., Schmitt, B., Linz, P., Laun, F., et al. (2018). Multiple Interleaved Mode Saturation (MIMOSA) for B1+ inhomogeneity mitigation in chemical exchange saturation transfer. Poster presented at Joint Annual Meeting ISMRM-ESMRMB 2018, Paris, France.


Cite as: http://hdl.handle.net/21.11116/0000-0001-7D84-E
Abstract
Due to high sensitivity to B1+-inhomogeneities, Chemical Exchange Saturation Transfer MRI requires a correction or mitigation of the B1+-inhomogeneity at ultra-high magnetic field strengths (B0 ≥ 7 Tesla). A novel approach for mitigation of B1+-inhomogeneity effects that affects the saturation process is presented. The method employs two interleaved excitation modes during the saturation pulse train. Simulations show a decrease of the relative difference of the MTRRex metric caused by B1+ inhomogeneity. This “Multiple Interleaved Mode Saturation” scheme leads to improved homogeneity in both, phantom and in vivo measurements at 7 Tesla.