MEMRI Reveals Plasticity Changes in the Auditory Midbrains of Mice After 
Two-Tone Rearing

Yu, X; Sanes, DH; Zou, J; Aristizábal, O; Zaim, YW; Turnbull, DH

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MEMRI Reveals Plasticity Changes in the Auditory Midbrains of Mice After Two-Tone Rearing

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https://cds.ismrm.org/ismrm-2007/files/1_program.pdf
(Abstract)

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Citation

Yu, X., Sanes, D., Zou, J., Aristizábal, O., Zaim, Y., & Turnbull, D. (2007). MEMRI Reveals Plasticity Changes in the Auditory Midbrains of Mice After Two-Tone Rearing. In 2007 Joint Annual Meeting ISMRM-ESMRMB (pp. 480).

Cite as: https://hdl.handle.net/21.11116/0000-0004-49E0-D

Abstract

We report that large-scale reorganization of
the mouse auditory midbrain tonotopic map is induced by a specific sound rearing e
nvironment consisting of
paired low and high frequency t
ones. Using a Manganese enhanced MRI (MEMRI) t
echnique with 100 micron resolution, we found that
two-tone rearing
prevented the appearance of separated frequency-specific respons
es; instead, a significant volume of the auditory midbrain beca
me responsive to both
rearing frequencies. Our study characteri
zed the developmental plasticity in the a
uditory midbrain, providing a critical workin
g model to study the experience dependent plasticity using MEMRI.