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Meeting Abstract

MEMRI Reveals Plasticity Changes in the Auditory Midbrains of Mice After Two-Tone Rearing

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Citation

Yu, X., Sanes, D., Zou, J., Aristizábal, O., Zaim, Y., & Turnbull, D. (2007). MEMRI Reveals Plasticity Changes in the Auditory Midbrains of Mice After Two-Tone Rearing. In 2007 Joint Annual Meeting ISMRM-ESMRMB (pp. 480).


Cite as: http://hdl.handle.net/21.11116/0000-0004-49E0-D
Abstract
We report that large-scale reorganization of the mouse auditory midbrain tonotopic map is induced by a specific sound rearing e nvironment consisting of paired low and high frequency t ones. Using a Manganese enhanced MRI (MEMRI) t echnique with 100 micron resolution, we found that two-tone rearing prevented the appearance of separated frequency-specific respons es; instead, a significant volume of the auditory midbrain beca me responsive to both rearing frequencies. Our study characteri zed the developmental plasticity in the a uditory midbrain, providing a critical workin g model to study the experience dependent plasticity using MEMRI.