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Journal Article

Virulence gene regulation by l-Arabinose in Salmonella enterica

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López-Garrido, J., Puerta-Fernández, E., Cota, I., & Casadesús, J. (2015). Virulence gene regulation by l-Arabinose in Salmonella enterica. Genetics, 200(3), 807-819. doi:10.1534/genetics.115.178103.

Cite as: http://hdl.handle.net/21.11116/0000-0006-AAF8-3
Invasion of the intestinal epithelium is a critical step in Salmonella enterica infection and requires functions encoded in the gene cluster known as Salmonella Pathogenicity Island 1 (SPI-1). Expression of SPI-1 genes is repressed by l-arabinose, and not by other pentoses. Transport of l-arabinose is necessary to repress SPI-1; however, repression is independent of l-arabinose metabolism and of the l-arabinose-responsive regulator AraC. SPI-1 repression by l-arabinose is exerted at a single target, HilD, and the mechanism appears to be post-translational. As a consequence of SPI-1 repression, l-arabinose reduces translocation of SPI-1 effectors to epithelial cells and decreases Salmonella invasion in vitro. These observations reveal a hitherto unknown role of l-arabinose in gene expression control and raise the possibility that Salmonella may use L-arabinose as an environmental signal.