English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
  Local TagsRelease HistoryDetailsSummary

Released
Journal Article

Genetic diversity of HLA system in three populations from Chihuahua, Mexico: Chihuahua City, Ciudad Juárez and rural Chihuahua

MPS-Authors
/persons/resource/persons214002

Barquera,  Rodrigo       
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons202721

Clayton,  S.
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Pacheco-Ubaldo, H., Adalid-Sáinz, C., Barquera, R., Clayton, S., Arrieta-Bolaños, E., Delgado-Aguirre, H., et al. (2020). Genetic diversity of HLA system in three populations from Chihuahua, Mexico: Chihuahua City, Ciudad Juárez and rural Chihuahua. Human Immunology, 81(9), 485-488. doi:10.1016/j.humimm.2019.05.014.


Cite as: https://hdl.handle.net/21.11116/0000-0007-3006-C
Abstract
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 461 Mexicans from the state of Chihuahua living in Chihuahua city (N = 119), Ciudad Juárez (N = 106) and rural communities (N = 236), to obtain information regarding allelic and haplotypic frequencies and their linkage disequilibrium. We find that the most frequent haplotypes found in the state of Chihuahua include seven Native American and three European haplotypes. Admixture estimates revealed that the main genetic components in Chihuahua are European (52.12 ± 0.88 by ML; 41.53 of European haplotypes) and Native American (39.51 ± 2.17 by ML; 37.45 of Native American haplotypes), while African genetic component was less apparent (8.36 ± 1.47 by ML; 11.70 of African haplotypes).