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Journal Article

Signature of consciousness in brain-wide synchronization patterns of monkey and human fMRI signals


Deco,  Gustavo
Computational Neuroscience Group, Department of Information and Communication Technologies, Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain;
Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain;
Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
School of Psychological Sciences, Monash University, Melbourne, Australia;

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Hahn, G., Zamora-López, G., Uhrig, L., Tagliazucchi, E., Laufs, H., Mantini, D., et al. (2021). Signature of consciousness in brain-wide synchronization patterns of monkey and human fMRI signals. NeuroImage, 226: 117470. doi:10.1016/j.neuroimage.2020.117470.

Cite as: https://hdl.handle.net/21.11116/0000-0007-62A7-E
During the sleep-wake cycle, the brain undergoes profound dynamical changes, which are manifested subjectively as transitions between conscious experience and unconsciousness. Yet, neurophysiological signatures that can objectively distinguish different consciousness states based are scarce. Here, we show that differences in the level of brain-wide signals can reliably distinguish different stages of sleep and anesthesia from the awake state in human and monkey resting state data. Moreover, a whole-brain computational model can faithfully reproduce changes in global synchronization and other metrics such as the structure-function relationship, integration and segregation across vigilance states. We demonstrate that the awake brain is close to a Hopf bifurcation, which naturally coincides with the emergence of globally correlated fMRI signals. Furthermore, simulating lesions of individual brain areas highlight the importance of connectivity hubs in the posterior brain and subcortical structures in maintaining the model in the awake state, as predicted by graph-theoretical analyses of structural data.